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Abstract
Objective: To measure the thickness of Carotid Intima Media (CIMT) in patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and compare it with Controls, to establish the strong association of NAFLD with increased CIMT.
Method/Setting: Fifty four patients with sonographically proven NAFLD and 50 controls were examined for CIMT. Carotid scanning was performed on Aloka 3500 Doppler Unit.
Results: The mean Intima Media Thickness in NAFLD group was 0.80±0.12 and in controls 0.58±0.15 (p= <0.0001). Carotid plaque was found in 24.07% patients in NAFLD group.
Conclusion: NAFLD as an independent risk factor for atherosclerosis and cardiovascular disease. Measurement of CIMT is a reliable, non-invasive tool for early detection of atherosclerosis in these patients.
References
Raitakari OT, Juonala M, Kähönen M, Taittonen L, Laitinen T, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the cardiovascular risk in young Finns study. JAMA 2003; 290(17): 2277-83. http://dx.doi.org/10.1001/jama.290.17.2277
Kim JH, Kim SY, Jung ES, Jung SW, Koo JS, et al. Carotid Intima-Media Thickness Is Increased Not Only in Non-Alcoholic Fatty Liver Disease Patients but Also in Alcoholic Fatty Liver Patients. Digestion 2011; 84: 149-55. http://dx.doi.org/10.1159/000326854
Preiss D, Sattar N. Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations. ClinSci (Lond) 2008; 115(5): 141-50. http://dx.doi.org/10.1042/CS20070402
Caserta CA, Pendino GM, Amante A, Vacalebre C, Fiorillo MT, et al. Cardiovascular risk factors, nonalcoholic fatty liver disease, and carotid artery intima-media thickness in an adolescent population in southern Italy. Am J Epidem 2010; 171(11?: 1195-202.
Ramilli S, Pretolani S, Muscari A, Pacelli B, Arienti V. Carotid lesions in outpatients with nonalcoholic fatty liver disease. World J Gastroenterol 2009; 15(38?: 4770-74.
de Groot E, Hovingh GK, Weigman A, et al. Measurement of arterial wall thickness as a surrogate marker for atherosclerosis. Circulation 2004; 109(23?: III33-III38.
Gansso A, Irace C, Mattioli PL, et al. Carotid intima media thickness and coronary heart disease risk factors. Atherosclerosis 1996; 119(1?: 7-15.
Kilciler G, Genc H, Tapan S, Ors F, Kara M, et al. Mean platelet volume and its relationship with atherosclerosis in subjects with non-alcoholic fatty liver disease. Upsala J Med Sci 2010; 115: 253-59. http://dx.doi.org/10.3109/03009734.2010.500062
Salonen JT, Salonen R. Ultrasound B mode imaging in observational studies of atherosclerotic progression. Circulation 1993; 87(3?: II56-58. http://dx.doi.org/10.1056/NEJM199901073400103
O’Leary DH, Polak JF, Kornmal RA, Manolio TA, Burke GL, et al. Carotid artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999; 340: 14-22.
Palmentieri B, de Sio I, La Mura V, Masarone M, Vecchione R, et al. The role of bright liver echo pattern on ultrasound B-mode examination in the diagnosis of liver steatosis. Dig Liver Dis 2006; 38: 485-89. http://dx.doi.org/10.1016/j.dld.2006.03.021
Carallo C, Mancuso G, Mauro G, Laghi F, Madaferri B, et al. Hepatic steatosis, carotid atherosclerosis and metabolic syndrome: The STEATO study. J Gastroenterol 2009; 44: 1156-61.
Targher G, Bertolini L, Padovani R, Rodella S, Zoppini G, et al. Relations between carotid artery wall thickness and liver histology in subjects with nonalcoholic fatty liver disease. Diabetes Care 2006; 29: 1325-30. http://dx.doi.org/10.2337/dc06-0135
Collichio P, Tarantino G, delGenio F, et al. Non-alcoholic fatty liver disease in young adult severely obese non-diabetic patients in South Italy. Ann Nutr Metab 2005; 49(5?: 289-95.
Quiros-Tejeira RE, Rivera CE, Zibba TT, et al. Risk for non-alcoholic fatty liver disease in Hespanic youth with BMI ?95th percentile. J Pediatr Gastroenterol Nutr 2007; 44(2?: 228-36.
Mohamadi A, Ghasemi-Rad M, Zahedi H, Toldi G, Alinia T. Effect of severity of steatosis as assessed ultrasonographically on hepatic vascular indices in non-alcoholic fatty liver disease. Med Ultrason 2011; 13(3?: 200-6.
Mohammadi A, Bazzazi A, Ghamesi-Rad M. Evaluation of atherosclerotic findings in patients with nonalcoholic fatty liver disease. Int J Gen Med 2011; 4: 717-22. http://dx.doi.org/10.2147/IJGM.S25753
Poanta IP, Albu A, Fodor D. Association between fatty liver disease and carotid atherosclerosis in patients with uncomplicated type 2 diabetes mellitus. Med Ultrasonogr 2011; 13(3?: 215-9.
Petit JM, Guiu B, Terriat B, Loffroy R, Robin I, et al. Non-alcoholic fatty liver disease is not associated with carotid intima-media thickness in type 2 diabetic patients. Clin Endocrinol Metab 2009; 94: 4103-6. http://dx.doi.org/10.1210/jc.2009-0541
Vlachopoulos C, Manesis E, Baou K, Papatheodoridis G, Koskinas J, et al. Increased arterial stiffness and impaired endothelial function in non-alcoholic fatty liver disease:A Pilot Study. Am J Hypertension 2010; 23(11?: 1183-89.
Koskinen J, Magnussen CG, Kahonen M, Loo B, Marniemi J. Association of liver enzymes with metabolic syndrome and carotid atherosclerosis in young adults. The cardiovascular risk in Young Finns Study. Ann Med 2011; 1-9.
Persighin G. The role of non-alcoholic fatty liver disease in Cardiovascular disease. Dig Dis 2010; 28: 210-13. http://dx.doi.org/10.1159/000282088
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Copyright (c) 2013 Aashfa Hassan Shaikh, Sabeen Aatif , Tanweer Ahmed