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Abstract
Anemia is the most commonly found blood disorder worldwide in the pregnant women and most frequently it is brought on by nutritional deficiencies giving rise to the typical Iron Deficiency Anemia (IDA). Intravenous administration of iron sucrose, provides a rapid mean to treat this condition by fulfilling the increased body demand of iron. Various alternate brands of iron sucrose injections are now available in the market place but a rationale is to be developed for a preferred product, based on its safety and efficacy. This retrospective comparative analysis is designed to compare two different brands, Megafer® injection and Venofer® injection, containing the same generic compound of Iron Sucrose, in Asian pregnant women with Iron Deficiency Anemia. The outcome measure for efficacy was targeted as the increase in levels of hemoglobin (Hb) after the drug administration, as per the approved protocol. The Hb levels were evaluated through hematological parameters while safety was analyzed by measuring the vital signs and any adverse event reported during the whole study period. Megafer® Injection was found to be as effective and safe as Venofer® Injection, for the short term treatment of IDA in pregnant women.
References
Organization, World Health. Iron deficiency anemia assessment prevention and control: a guide for program managers. Geneva: World Health Organization 2001.
World Bank. Prevalence of anemia among pregnant women (%). [Online
McLean E. Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System. WHO 2008.
Brabin JAB. The Risks of Severity of Malaria in Pregnant Women. Geneva: World health Oganization. Applied field research in malaria.
De Mayer EM. Preventing and Controlling Iron Deficiency Anaemia Through Primary Health Care. Geneva: WHO 1989.
Harrison CKA. Maternal Mortality and Anaemia in Pregnancy. W Afr Med J 1975.
Allen LH. Anemia and iron deficiency: Effects on pregnancy. s.l.: J Clin Nutr 2000.
Morristown NJ. INFeD (iron dextran injection) product information. Watson Pharma, Inc. September 2009.
DexFerrum (iron dextran injection) product information. Shirley, NY: American Regent 2008.
Bilqis H, Chaudhri R. Efficacy and safety of iron sucrosecomplex (Ferotein-S) in the treatment of iron deficiencyanaemia in pregnant women at Holy Family HospitalRawalpindi. s.l.: J of Soci of Obst Gynaecolo of Pak – JSOGP.
Bushra A, et al. 1The role of intravenous iron sucrose complex in treatment of iron deficiency anemia in pregnant women. s.l.: ISRA Medical Journal 2015; 7.
Agrawal D, Fotedar S, Kundu S, Mourya M. Iron sucrose infusion in pregnancy: made easy. s.l.: Annals of Applied Bio-sciences 2014.
Wali A, Mushtaq A, Nilofer. Comparative Study - Efficacy, Safety and Compliance of Intravenous Iron Sucrose and Intramuscular Iron Sorbitol in Iron Deficiency Anemia of Pregnancy. s.l.: J Pak Med Assoc., 2002.
Breymann C. Iron deficiency and anaemia in pregnancy: modern aspects of diagnosis and therapy. s.l.: Blood Cells Mol Dis 2002; 29.
Komolafe JO, Kuti O, Ijadunola KT, Ogunniyi SO. A comparative study between intramuscular iron dextran and oral ferrous sulphate in the treatment of iron deficiency anaemia in pregnancy. s.l.: J Obstet Gynaecol.
Raja KS, Janjua NB, Khokhar N. Intravenous iron sucrose complex therapy in iron defeciency anemia in the pregnant women. s.l.: Rawal Med J.
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Copyright (c) 2018 Haleema Yasmin, Ghazala Ishrat, Quratulain N. Siddiqui, Sohaib Yahya, Najia Mansoor , Mohsin Ali