Prevalence of Hepatitis B Surface Antigen (HBsAg) Among HIV Seropositive Patients
PDF

Keywords

 HIV, HBsAg, HBV, Co-infection, Prevalence

How to Cite

Anamika Vyas, Ramavtar Saini, & Pooja Gangrade. (2012). Prevalence of Hepatitis B Surface Antigen (HBsAg) Among HIV Seropositive Patients. Journal of Basic & Applied Sciences, 8(1), 243–246. https://doi.org/10.6000/1927-5129.2012.08.01.37

Abstract

Introduction: Human Immunodeficiency Virus (HIV) and Hepatitis B virus (HBV) share the routes of transmission as a consequences infection with Hepatitis B Virus are expected to occur in HIV infected patients. The co-infection of Hepatitis B Virus (HBV) with the Human Immunodeficiency Virus (HIV) have become a major health care catastrophe as it complicates the clinical course, management and therapy for HIV infection. Hence it is important to identify them as early as possible.

Aim: The prevalence of HBV co-infection with HIV varies widely across different studies within India and outsides. This study is planned to evaluate the prevalence of HIV-HBV co-infection by HBsAg screening in HIV seropositive patients in our region.

Material and Method: A total of 140 HIV seropositive patients were screened for the presence of Hepatitis B virus on the basis of the presence of HBsAg.

Result: In patients infected with HIV the prevalence of HBsAg was 7.1% (10/140) wherease in control group it was 1% (5/500).

Discussion: Our study documents fairly high rate of Hepatitis B co-infection among HIV seropositive patients suggesting that it should be mandatory to screen every HIV seropositive patient and their sexual partners for co infection with HBV and vice versa for early detection and a simultaneous treatment of hepatitis B co-infection beside HIV infection management to reduce the morbidity, delay mortality and improve quality of life in HIV-AIDS patients.

https://doi.org/10.6000/1927-5129.2012.08.01.37
PDF

References

Alter MJ. Epidemiology of viral hepatitis and HIV co infection. J Hepatol 2006; 44(Suppl 1): S6-9. http://dx.doi.org/10.1016/j.jhep.2005.11.004

McNair AN, Main J, Thomas HS. Interaction of Human immunodeficiency virus and of hepatotropic viruses. Semin Liver Dis 1992; 12 May(2): 188-96. http://dx.doi.org/10.1055/s-2007-1007390

Smith PD, Quinn TC, Strober W. Gastrointestinal infections in AIDS. Ann Intern Med 1992; 116: 63-67.

Rustgi VK, Hoofnagle JH, Gerin JL, et al. Hepatitis B virus infection in the acquired immunodeficiency syndrome. Annal Intern Med 1984; 795-97.

Scharschmidt BF, Held MJ, Hollander HH, Read AE, Lavine JE, Veereman G. Hepatitis B in patients with HIV infection: relationship to AIDS and patient survival. Ann Intern Med 1992; 117: 837-38.

Halder SC, Judson FN, O’Malley PM, Altmen NC, Penley K, Buchbinder S. Outcome of hepatitis B virus infection in homosexual men nd its relation to prior human immunodeficiency virus. J Infect Dis 1991 163: 454-59. http://dx.doi.org/10.1093/infdis/163.3.454

Housset C, Pol S, Carnot F, Dubois F, Nalpas B, Housset B. Interaction between human immunodeficiency virus, hepatitis Delta virus and hepatitis B virus infection in 260 chronic carriers of hepatitis B virus hepatology 1992; 15: 578-83.

Gilson RJ, Hawkins AE, Beecham MR, et al. Interaction between HIV and hepatitis B virus in homosexual men: effect on the natural history of infection. AIDS 1997; 11: 597-606. http://dx.doi.org/10.1097/00002030-199705000-00007

Eskild A, Magnum P, Petersen G, et al. Hepatitis B antibodies in HIV infected homosexual men are associated with more rapid progression to AIDS. AIDS 1992; 6: 571-74. http://dx.doi.org/10.1097/00002030-199206000-00008

Thio CL, Scaberg EC, Skolasky R Jr, et al. HIV-1, hepatitis B virus and risk of liver related mortality in the Multicenter cohort study (MACS). Lancet 2002; 360: 1921-6. http://dx.doi.org/10.1016/S0140-6736(02)11913-1

Shobha Sehgal, Shiraj Mujtaba. Prevalence of HBsAg in patient with HIV infection. Ind J Gastroenterol 1998; 17: 35.

Suwmanagool S, Treangrims, Ratnaswami W, Mekantgosal S, Luengrojanakul P, Kunasol P. Sero prevalence of HBsAg and anti HCV among HIV infected persons and general population. J Med Ass Thailand 1995; 78: 611-17.

Dhanvijay AG, Thakar YS, Chande CA, et al. Hepatitis B virus infection in HIV infected patients. Indian J Med Microbiol 1999; 17(4): 167-69.

Tankhiwale SS, Khadase RK, Jalgoankar SV. Sero prevalence of anti HCV and hepatitis B surface antigen in HIV infected patients. Ind J Med Microbiol 2003; 21(4): 268-70.

Sud A, Singh J, Dhiman RK, Wanch UA, Singh S. Hepatitis B virus co-infection in HIV infected patients. Trop Gastroentero 2001; 22-23.

McDonald JA, Caruso L, Karayiannis P, et al. Diminished responsiveness of male homosexual chronic hepatitis B virus carriers with HTLV-III antibodies to recombinant alfa interferon. Hepatology 1987; 7: 719-723. http://dx.doi.org/10.1002/hep.1840070417