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Abstract
Chronic Fatigue Syndrome is an illness of unknown aetiology that has been associated with abnormalities in essential fatty acid metabolism, however this still remains unclear. We have compared the fatty acid profile in plasma and red blood cells and their dietary intake between a group of 20 patients diagnosed with CFS (18 women and 2 men) and 20 aged- sex- diet- low activity- matched controls. Compared to the controls, CFS patients show a decrease in the proportion of linoleic acid (t: 2.137, p: 0.039) and an increase in that of stearic acid (t: 2.602, p: 0.013) in plasma, however such differences have not been observed in the fatty acid profile of red blood cells. In these cases, no direct relationship has been observed between the dietary intake and fatty acid profile. Therefore, these results do not give support that long-chain polyunsaturated fatty acids may contribute in the better course of the pathology.
References
Fukuda K, Straus S, Hickie I. The chronic fatigue síndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994; 121: 953-9.
Simopoulos A P. Essential fatty acids in health and chronic disease. Am J Clin Nutr. 1999; 70 (suppl): 560s-9s.
Simopoulos A P. Omega 3 fatty acids in inflammation and autoimmune diseases. J Am Col Nutr. 2002; 21 : 495-505.
Lefkowith J B, Morrison A, Lee V, Rogers M. Manipulation of acute inflammatory response by dietary polyunsaturated fatty acid modulation. The Journal of Immunology. 1990; 145: 1523-9.
Mantzioris E, Cleland L G, Gibson R A, Neumann M A, Demasi M, James M J. Biochemical effects of a diet containing foods enriched with n-3 fatty acids. Am J Clin Nutr. 2000; 72: 42-8.
Simmopoulos A P. The importance of the ratio of omega-6/omega-3 essential fatty acids Biomed Pharmacother. 2002; 56: 365-79.
http://dx.doi.org/10.1016/S0753-3322(02)00253-6
Haag M. Essential fatty acids and the brain. Can J Psychiatry. 2003; 48: 195-203.
Tamizi Bfar, Tamizi B. Treatment of chronic fatigue syndrome by dietary supplementation with w-3 fatty acids-a good idea? Medical Hypotheses. (2002) 58(3), 249-50.
http://dx.doi.org/10.1054/mehy.2001.1507
Puri B K, Holmes J, Hamilton G. Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes. Int J Clin Pract. 2004; 58: 297-9.
http://dx.doi.org/10.1111/j.1368-5031.2004.00073.x
Puri BK. The use of eicosapentaenoic acid in the treatment of chronic fatigue syndrome. Prost Leu Essent Fatty Acids. 2004; 70: 399-401.
http://dx.doi.org/10.1016/j.plefa.2003.12.015
Behan P O, Behan W M H, Horrobin D F. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. Acta Neurol Scand. 1990; 82: 209-16.
http://dx.doi.org/10.1111/j.1600-0404.1990.tb04490.x
Liu Z, Wang D, Xue Q, Chen J, Li Y, Bai X, Chang L. Determination of Fatty Acid Levels in Erythrocyte Membranes of Patients with Chronic Fatigue Syndrome. Nutr Neuro. 2003; 6: 389-92.
http://dx.doi.org/10.1080/10284150310001640356
Maes M, Mihaylova I, Leunis JC. In chronic fatigue syndrome, the decreased levels of omega-3 poly-unsaturated fatty acids are related to lowered serum zinc and defects in T cell activation. Neuro Endocrinol Lett. 2005 Dec;26(6):745-51.
Puri BK. Long-chain polyunsaturated fatty acids and the pathophysiology of myalgic encephalomyelitis (chronic fatigue syndrome). Review. J Clin Pathol. 2007; 60: 122-4.
http://dx.doi.org/10.1136/jcp.2006.042424
Warren G, McKendrick M, Peet M. The role of essential fatty acids in chronic fatigue syndrome: a case-controlled study of red cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. Acta Neurol Scand. 1999; 99: 112-6.
http://dx.doi.org/10.1111/j.1600-0404.1999.tb00667.x
Li YJ, Wang DX, Bai XL, Chen J, Liu ZD, Feng ZJ, Zhao YM. Clinical characteristics of patients with chronic fatigue syndrome: analysis of 82 cases. Zhonghua Yi Xue Za Zhi. 2005 Mar 16;85(10):701-4.
FAO/WHO-OMS/UNU Expert consultation report. Energy and Protein Requirements. Technical Report Series 724. Ginebra: WHO/OMS. 1985.
Tamizi far B, Tamizi B. Treatment of chronic fatigue syndrome by dietary supplementation with w-3 fatty acids – a good idea? Med Hypotheses. 2002; 58: 249-50.
Gray J B, Martinovic A M. Eicosanoids and essential fatty acid modulation in chronic disease and the chronic fatigue syndrome. Med Hypotheses. 1994; 43: 31-42.
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Copyright (c) 2011 Ramon Segura, Casimiro Javierre, Magda Rafecas, Josep L Ventura, Laura Arranz, Gemma Miranda