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Abstract
Several studies has pointed that red wine diet, rich in polyphenols, has several effects like vasodilation, possible antioxidant effect, decrease of cellular events of atherosclerosis, decrease of blood pressure, and reduction of cardiovascular risks. This paper proposes an investigation of the effects of a 21 days diet of 200 ml dialy of red dry wine for markers of muscle injury such as CK and CK-MB, besides cholesterol and its fractions, LDL and HDL, and triglycerides, in normal subjects.The results showeddecreased levels of plasma total cholesterol and LDL, and a tendency to increased levels of HDL, what suggests red dry wine has effects on decrease cardiovascular risks. However, significant increase of cardiacCK-MB isoenzyme was observed what could point to increase the oxidation of muscle tissues. It can be concluded that, despite the CK-MB increase, red dry wine can be considered as a tool to decrease cardiovascular diseases risks.
References
DaLuz PL, Coimbra SR. Wine, alcohol and atherosclerosis: clinical evidences and mechanisms. Braz J Med Biol Res 2004; 37(9): 1275-95. http://dx.doi.org/10.1590/S0100-879X2004000900001
Berliner JA, Navab M, Fogelman AM, et al. Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation 1995; 91: 2488-96.
Grundtman C, Wick G. The autoimmune concept of atherosclerosis. Curr Opin Lipidol 2011; 22(5): 327-34. http://dx.doi.org/10.1097/MOL.0b013e32834aa0c2
Andrade ACM, Cesena FHY, Consolim-Colombo FM, et al. Short-term red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjects. Clinics 2009; 64(5): 435-42. http://dx.doi.org/10.1590/S1807-59322009000500011
Catapano AL, Maggi FM, Tragni E. Low density lipoprotein oxidation, antioxidants, and at herosclerosis. Curr Opin Cardiol 2000; 15(5): 355-63. http://dx.doi.org/10.1097/00001573-200009000-00008
Pérez-Guisado J, Muñoz-Serrano A, Alonso-Moraga A. Spanish Ketogenic Mediterranean Diet: a healthy cardiovascular diet for weight loss. Nutr J 2008; 7: 30. http://dx.doi.org/10.1186/1475-2891-7-30
Dani C, Oliboni LS, Umezu FM, et al. Antioxidant and antigenotoxic activities of purple grape juice – organic and conventional – in adult rats. J Med Food 2009; 12, 1111-18. http://dx.doi.org/10.1089/jmf.2008.0256
Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols, anti-inflammatory antioxidant and DNA repair mechanisms. Arch Dermatol Res 2001; 302: 71-83. http://dx.doi.org/10.1007/s00403-009-1001-3
Sharma SD, Meeran SM, Katiyar SK. Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-kappaB signaling in in vivo SKH-1 hairless mice. Mol Cancer Ther 2007; 6: 995-1005. http://dx.doi.org/10.1158/1535-7163.MCT-06-0661
Vitseva O, Varghese S, Chakrabarti S, Folts JD, Freedman JE. Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. J Cardiovasc Pharmacol 2005; 46: 445-51. http://dx.doi.org/10.1097/01.fjc.0000176727.67066.1c
Lippi G, Franchini G, Favaloro G. Moderate red wine consumption and cardiovascular disease risk, beyond the ‘French paradox’. Semin Thromb Hemost 2010; 36: 59-70. http://dx.doi.org/10.1055/s-0030-1248725
De Lorgeril M, Salen P, Martin JL, Monjaud I, Delaye J, Manelle N. Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction. Circulation 1999; 99: 779-85.
Albert CM, Manson JE, Cook NR, Ajani UA, Gaziano JM, Hennekens CH. Moderate alcohol consumption and the risk of sudden cardiac death among US male physicians. Circulation 1999; 10: 944-50.
Di Castelnuovo A, Rotondo S, Iacoviello L, Donati MB, Gaetano G. Meta-analysis of wine and beer consumption in relation to vascular risk. Circulation 2002; 105: 2836-44. http://dx.doi.org/10.1161/01.CIR.0000018653.19696.01
Doll R, Peto R, Hall E, Wheatley K, Gray R. Mortality in relation to consumption of alcohol: 13 years' observations in male British doctors. Br Med J 1994; 309: 911-18. http://dx.doi.org/10.1136/bmj.309.6959.911
Da Luz PL, Serrano Jr CV, Chacra AP, et al. The effect of red wine on experimental atherosclerosis: lipid-independent protection. Exp Mol Patho 1999; 65: 150-59. http://dx.doi.org/10.1016/S0014-4800(99)80004-5
Hayek T, Fuhrman B, Vaya J, et al. Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler Thromb Vasc Biol 1997; 17: 2744-52. http://dx.doi.org/10.1161/01.ATV.17.11.2744
Rosenkranz S, Knirel D, Dietrich H, Flesh M, Erdmann E, Bohm M. Inhibition of the PDGF receptor by red wine flavonoids provides a molecular explanation for the "French paradox". FASEB J 2002; 16: 1958-60.
Corder R, Douthwaite JÁ, Lees DM, et al. Health: endothelin-I synthesis reduced by red wine. Nature 2001; 414: 863-64. http://dx.doi.org/10.1038/414863a
Hashimoto M, Kim S, Eto M, et al. Effect of acute intake of red wine on flow-mediated vasodilatation of the brachial artery. Am J Cardiol 2001; 88: 1457-60. http://dx.doi.org/10.1016/S0002-9149(01)02137-3
Matsuo S, Nakamura Y, Takahashi M, et al. Effect of red wine and ethanol on production of nitric oxide in healthy subjects. Am J Cardiol 2001; 87: 1029-31. http://dx.doi.org/10.1016/S0002-9149(01)01446-1
Erkasap N, Dernek S, Kural T, Kaygisiz Z. Dietary polyphenol quercetin protects rat hearts during reperfusion: enhanced antioxidant capacity with chronic treatment. Anadolu Kardiyol Derg 2007; 7(4): 404-10.
Young DS. Effects of disease on clinical lab tests, 4th ed, AACC, 2001.
Stampfer MJ, Colditz GA, Willet WC, Splizer FE, Hennekens CH. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. NEJ Med 1988; 31: 267-73. http://dx.doi.org/10.1056/NEJM198808043190503
Klatsky AL, Friedman GD, Armstrong MA. The relationships between alcoholic beverage use and other traits to blood pressure: a new Kaiser Permanent Study. Circulation 1986; 73: 628-636. http://dx.doi.org/10.1161/01.CIR.73.4.628
Coimbra SR, Lage SH, Brandizzi L, Yoshida V, Da Luz PL. The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients Braz J Med Biol Res 2005; 38(9): 1339-47. http://dx.doi.org/10.1590/S0100-879X2005000900008
Lavy A, Fuhrman B, Markel A, et al. Effect of dietary supplementation of red or white wine on human blood chemistry, hematology and coagulation: favorable effect of red wine on plasma high-density lipoprotein. Ann Nutr Metab 1994; 38(5): 287-94. http://dx.doi.org/10.1159/000177823
Kaul S, Belcik T, Kalvaitis S, Jayaweera AR, Choi SW, Wei K. Effect of modest alcohol consumption over 1-2 weeks on the coronary microcirculation of normal subjects. Eur J Echocardiogr 2010; 11(8): 683-9. http://dx.doi.org/10.1093/ejechocard/jeq042
Rodrigo R, Bosco C, Herrera P, Rivera G. Amelioration of myoglobinuric renal damage in rats by chronic exposure to flavonol-rich red wine. Nephrol Dial Transplant 2004; 19(9): 2237-44. http://dx.doi.org/10.1093/ndt/gfh369
Siegel AJ, Dawson DM. Nonspecificity of MB isoenzyme for myocardial injury in undiluted serum samples. JAMA 1980; 244(6): 580-2. http://dx.doi.org/10.1001/jama.1980.03310060036019
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Copyright (c) 2012 Rogério Corrêa Peres, Rafael Hirata, Samuel Rangel Claudio, Taina Liz, Tamires Corrêa da Silva , Daniel Araki Ribeiro