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Abstract
Cancer prevention is an important problem in the field of public health. Glycyrrhizin, a natural sweetening agent, is one of the components of licorice and caffeine in coffee and tea. Glycyrrhizin and caffeine were found to inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in two-stage carcinogenesis in mouse skin. Furthermore, the combined treatment of glycyrrhizin and caffeine is more effective than their single treatment on tumor promotion by TPA in mice following initiation with 7,12-dimethylbenz[a]anthracene.
References
Yasukawa K. Medicinal and edible plants as cancer preventive agents. In: Vallisuta O, Olimat SM. Eds. Drug discovery research in pharmacognosy. Croatia: InTech 2012; 181-208. http://www.intechopen.com/books/drug-discovery-research-in-pharmacognosy/medicinal-and-edible-plants-as-cancer-preventive-agent
Yasukawa K, Takido M, Takeuchi M, Nakagawa S. Inhibitory effect of glycyrrhizin and caffeine on two-stage carcinogenesis in mice. Yakugaku Zasshi 1988; 108: 794-6. https://www.jstage.jst.go.jp/article/yakushi1947/108/8/108_8_794/_pdf
Nishino H, Kitagawa K, Iwashima A. Antitumor-promoting activity of glycyrrhetic acid in mouse skin tumor formation induced by 7,12-dimethylbenz[a
Nishino H, Yoshioka K, Iwashima A, Takizawa H, Konishi S, Okamoto H, et al. Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12-O-tetradecanoylphorbol-13-acetate in two-stage mouse skin carcinogenesis. Jpn J Cancer Res (Gann) 1986; 77: 33-8.
O’Brian CA, Ward NE, Vogel VG. Inhibition of protein kinase C by the 12-O-tetradecanoylphorbol-13-acetate antagonist glycyrrhetic acid. Cancer Lett 1990; 49: 9-12. http://dx.doi.org/10.1016/0304-3835(90)90132-H
Jeong HG, Kim JY. Induction of inducible nitric oxide synthase expression by 18?-glycyrrhetinic acid in macrophages. FEBS Lett 2002; 513: 208-12. http://dx.doi.org/10.1016/S0014-5793(02)02311-6
Shiota G, Harada K, Ishida M, Tomie Y, Okubo M, Katayama S, et al. Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice. Carcinogenesis, 1999; 20: 59-63. http://dx.doi.org/10.1093/carcin/20.1.59
Nishino H, Yoshioka K, Iwashima A, Takizawa H, Konishi S, Okamoto H, et al. Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12-O-tetradecanoylphorbol-13-acetate in two-stage mouse skin carcinogenesis. Jpn J Cancer Res (Gann) 1986; 77: 33-8.
Yasukawa K, Takahashi H, Kitanaka S, Hirayama H, Shigemoto K. Inhibitory effect of an aqueous extract of Phellinus linteus on tumor promotion in mouse skin. Mushroom Sci Biotechnol 2007; 15: 97-101.
Yasukawa K. Cancer chemopreventive agents: natural pentacyclic triterpenoids. In: Salvador JAR, Ed. Pentacyclic triterpenes as promising agents in cancer. New York: Nova Science Publishers, Inc. 2010; pp. 127-57. https://www. novapublishers.com/catalog/product_info.php?products_id=42026&osCsid=ef162d372876b292c2f816e648733c74
Yasukawa K. Cancer chemopreventive agents: Tetracyclic triterpenoids. In: Watanabe HS, editor. Horizons in cancer research. New York: Nova Science Publishers, Inc. 2013; Vol. 51: pp. 89-113. https://www.novapublishers.com/catalog/ product_info.php?products_id=12372
Narisawa T, Takahashi M, Masuda T, Nagasawa O, Koyama H. Prevention of peritoneal carcinogenesis recurrence with a prostaglandin synthesis inhibitor, indomethacin. Gan To Kagaku Ryoho (in Japanese) 1987; 14: 2496-501.
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Copyright (c) 2013 Ken Yasukawa