Keywords
How to Cite
Abstract
In this investigation, we revealed that application of the biostimulating tissue preparation based on chicken embryos (“STEMB”) at experimental hepatorenal syndrome showed improvement of the morphofunctional parameters of a liver. Under the influence of a biostimulator the relative mass of a liver considerably decreased and biochemical markers of a condition of a liver (total bilirubin, ALT, AST) returned to normal. Besides, under the influence of “STEMB” the tendency to normalization of mitotic, apoptotic and binuclear cells index of liver tissues and considerable decrease in a necrotic index is observed. Results of the research conducted by us allow to make a conclusion on possibility of inclusion of “STEMB” in a complex therapy of HRS for treatment of the injuries of a liver which are its main reason.
References
Davydov M, Krikorian AD. Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. J Ethnopharmacol 2000; 345-393. http://dx.doi.org/10.1016/S0378-8741(00)00181-1
Panossian A. Wilkman G. Effects of adaptogens on the central nervous system and the molecular mechanisms associated with their stress-protective activity. Pharmaceuticals 2010; 3: 188-224. http://dx.doi.org/10.3390/ph3010188
Chandika P, Ko S-C, Jung W-K. Marine-derived biological macromolecule-based biomaterials for wound healing and skin tissue regeneration. Int J Biol Macromol 2015: 77; 24-35. http://dx.doi.org/10.1016/j.ijbiomac.2015.02.050
Pawar VS, Shivakumar H. A current status of adaptogens: natural remedy to stress. Asian Pacific J Trop Dis 2012; 480-490.
Areshidze DA, Timchenko LD, Rzhepakovsky IV, Syomin IA, Kozlova MA, Sizonenko MN. Immunomodulatory influence of succinate extract of the Californian earthworms (Eisenia foetida). Cahiers des Sciences Naturelles 2014; 23: 2-12.
Hosseini SV, Hamzeh A, Moslemi M, Lashkan AB, Iglesias A, Feas X. Effect of delayed icing on biogenic amines formation and bacterial contribution of iced common carp (Cyprinus carpio). Molecules 2013; 18: 15464-15473. http://dx.doi.org/10.1111/j.1365-2621
Kashiwagi S. Brauns T, Gelfand J, Poznansky MC. Laser vaccine adjuvants: History, progress, and potential. Human Vaccines and Immunotherapeutics 2014; 10: 1892-1907. http://dx.doi.org/10.4161/hv.28840
Gomes A, Giri B, Alam A, Mukherjee S, Bhattacharjee P, Gomes A. Anticancer activity of a low immunogenic protein toxin (BMP1) from Indian toad (Bufo melanostictus, Schneider) skin extract. Toxicon 2011; 58: 85-92. http://dx.doi.org/10.1016/j.toxicon.2011.05.008
Di Nicola V, Di Nicola R. Self-repair in degenerative joint disease. Curr Aging Sci 2012; 5: 273-278. http://dx.doi.org/10.2174/1874609811205030015
Chakraborty PD, Bhattacharyya D., Zheng J. Aqueous extract of human placenta as a therapeutic agent. Recent Advances in research on the human placenta. Rijeka.: InTech 2012; 77-92. http://dx.doi.org/10.5772/31669
Filardo G, Kon E, Di Martino A, Di Matteo B, Merli ML, Cenacchi A, Fornasari PM, Marcacci M. Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial. BMC Musculoskelet. Disord 2012; 13: 1-8. http://dx.doi.org/10.1186/1471-2474-13-229
Shojaee M, Navaee F, Jalili-Firoozinezhad S, Faturechi R, Majidi M, Bonakdar S. Fabrication and characterization of ovalbumin films for wound dressing applications. Materials Science and Engineering 2015; 48: 158-164. http://dx.doi.org/10.1002/app.24537
Florescu S. Paraschiv S, Rarinca C, Stavri J, Constantinescu E, Radu A, Georgescu D, Radu A. Effect of biogenic stimulants in the early fattening of young sheep. Lucrarile Stiintifice ale Institutului de Cercetari pentru Nutritie Animala 1975; 117-130.
Tyagi JS, Merlino GT, de Crombrugghe B, Pastan I. Chicken embryo extracts contain a factor that preferentially blocks the accumulation of RNA polymerase II transcripts in a cell-free system. Journal of Biological Chemistry 1982; 257: 13001-13008.
Yagi A. Bioactive constituents of a human placenta hydrolysate – from biogenic stimulants reported by Filatow to biological markers of collagen generation. Natural Medicines 2004; 58: 121-131.
Huang D, Yang, Wang C, Ma S, Cui L, Huang S, Xu M, Sheng X, Weng Q. Immunostimulatory activity of protein hydrolysate from Oviductus Ranae on macrophage in vitro. Evidence-based Complementary and Alternative Medicine 2014; 2014: 1-11. http://dx.doi.org/10.1155/2014/180234
Skehel JM. Preparation of extracts from animal tissues. Methods in Molecular Biology 2004; 244: 15-20.
Oh TH, Markelonis GJ. Dependence of in vitro myogenesis on a trophic protein present in chicken embryo extract. Proceedings of the National Academy of Sciences 1980: 77; 6922-6925.
Yadgary L, Wong EA, Uni Z. Temporal transcriptome analysis of the chicken embryo yolk sac. BMC Genomics 2014; 15: 690. http://dx.doi.org/10.1186/1471-2164-15-690
Li X, Su Y, Sun J, Yang Y. Chicken embryo extracts enhance spleen lymphocyte and peritoneal macrophages function. Journal of Ethnopharmacology 2012; 144: 255-260.
Alibardi L, Mlitz V, Eckhart L. Immunolocalization of scaf-foldin, a trichohyalin-like protein, in the epidermis of the chic-ken embryo. The Anatomical Record 2015; 298: 279-287. http://dx.doi.org/10.1002/ar.23039
Sturgill MG, Lambert GH. Xenobiotic-induced hepatotoxity: mechanisms of liver injury and methods of monitoring hepatic function. Clinical Chemistry 1997; 43: 1512-1526.
Mudipalli A. Lead hepatotoxity & potential health effects. Indian. J Med Res 2007; 119: 1-2.
O’Shea RS, Dasarathy S, McCullough AJ. Alcoholic liver disease. Hepatology 2010; 51: 219-226. http://dx.doi.org/10.1002/hep.23258
Schjott J, Mizuguchi Y (Ed.). Adverse effects of drugs and toxins on the liver. Liver biopsy in modern medicine. Rijeka.: In Tech 2011; 137-162.
Kumar Seth R, Kumar A, Kumar Seth A, Chatterjee S. Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. Toxicological Sciences 2013; 134: 291-303. http://dx.doi.org/10.1093/toxsci/kft104
Ejtehadi A, Anushiravani A, Bananzadeh B, Geramizadeh F. Gastrointestinal Basidiobolomycosis accompanied by liver involvement: a case report. Iran. Red. Crescent. Med J 2014; 16: 1-5. http://dx.doi.org/10.5812/ircmj.14109
Chang Y, Qi X, Li F, Wang S, Wang Z, Zhang Z, Xiao C, Ding T, Yang C. Hepatorenal syndrome: insights into the mechanisms of intra-abdominal hypertension. Int J Clin Exp Pathol 2013; 6: 2523-2528.
Wong F, Blendis L. New challenge of hepatorenal syndrome: prevention and treatment. Hepatology 2001; 34: 1242-1251. http://dx.doi.org/10.1053/jhep.2001.2920
Schepke M. Hepatorenal syndrome: current diagnostic and therapeutic concepts. Nephrol Dial Transplant 2007; 22: 2-4. http://dx.doi.org/10.1093/ndt/gfm656
Assimakopoulos SF, Vagianos CE. Bile duct ligation in rats: A reliable model of hepatorenal syndrome? World J Gastroenterol 2009; 15: 121-123. http://dx.doi.org/10.3748/wjg.15.121
Arroyo V, Guevara M, Gines P. Hepatorenal syndrome in cirrhosis: pathogenesis and treatment. Gastroenterology 2002; 122: 1658-1676. http://dx.doi.org/10.1053/gast.2002.33575
Gordon CE. Hepatorenal syndrome. Hospital Medicine Clinics 2012; l: 62-68. http://dx.doi.org/10.1016/j.ehmc.2011.11.003
Wadei HM, Mai ML, Ahsan N, Gonwa TA. Hepatorenal syndrome: Pathophysiology and Management. Clin J Am Soc Nephrol 2006; 1: 1066-1079. http://dx.doi.org/10.1080/13651820701867935
Kashani A, Landaverde ?, Medici V, Rosarro L. Fluid retention in cirrosis: pathophysiology and management. Q J Med 2008; 10: 71-85. http://dx.doi.org/10.1093/qjmed/hcm12
Mammayev SN, Karimova ??. Hepatorenal syndrome of the 1-st and 2-nd type: state-of-the-art. Russian Journal of Gastroenterology, Hepatology, Coloproctology 2008; 6: 4-11.
Licata A, Maida M, Bonaccorso A, Macaluso FS, Capello M, Craxi A, Almasio PL. Clinical course and prognostic factors of hepatorenal syndrome: a retrospective single-center cohort study. World J Hepatol 2013; 12: 685-691. http://dx.doi.org/10.1002/hep.23286
Davidson AM. Hepatorenal failure. Nephrol Dial Transplant 1996; ?8: 24-31.
Nadim MK, Kellum JA, Davenport A, Wong F, Davis C, Pannu N, Tolwani A, Bellomo R, Genyk Y. Hepatorenal syndrome: the 8th international consensus conference of the Acute Dialysis Quality Initiative (ADQI) Group. Critical Care 2012; 16: 1-17. http://dx.doi.org/10.1186/cc11188
Blokhina NV, Pasechnik IN. The modern possibilities of the hepato-renal syndrome treatment. Surgery 2013; 8: 81-85.
Low G, Alexander DJ. Hepatorenal syndrome: Aetiology, diagnosis, and treatment. Gastroenterology Research and Practice 2015; 2015: 1-11. http://dx.doi.org/10.1155/2015/207012
Moore K. Endothelin and vascular function in liver disease. Gut 2004; 53: 159-161. http://dx.doi.org/10.1136/gut.2003.024703
Wong F. Treatment of hepatorenal syndrome. Indian Journal of Gastroenterology 2006; 25: 8-12.
Ng CKF, Chan MHM, Tai MHL, Lam CWK. Hepatorenal syndrome. Clin Biochem Rev 2007; 28: 11-17.
Martin-Llahi M, Pepin M-N, Guevara M, Diaz F, Torre A, Monescillo A, Soriano G, Terra C, Fabrega E, Arroyo V, Rodes J, Gines P. Terlipressin and albumin vs albumin in patients with cirrhosis and hepatorenal syndrome: a randomized study. Gastroenterology 2008; 134: 1352-1359.
Nazar A, Pereira G-P, Guevara M, Martin-Llahi M, Pepin M-N, Marinelli M, Sola E, Baccaro ME, Terra C, Arroyo V, Gines P. Predictors of response to therapy with terlipressin and albumin in patients with cirrhosis and type 1 hepatorenal syndrome. Hepatology 2010; 51: 219-226. http://dx.doi.org/10.1177/2050640613502900
Boyer TD, Sanyal TD, Boyer A, Garsia-Tsao A. Predictors of response to terlipressin plus albumin in hepatorenal syndrome (HRS) type 1: Relationship of serum creatinine to hemodynamics. J Hepatol 2011; 55: 315-321. http://dx.doi.org/10.1016/j.jhep.2010.11.020
Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: A food plant with multiple medicinal uses. Phytother Res 2007; 21: 17-25. http://dx.doi.org/10.1002/ptr.2023
Areshidze DA, Timchenko LD, Klimenko AI, Gulykin MI, Kozlova MA. Influence of an enzymatic hydrolyzate of Chlorophytum comosum (L.) on morphofunctional integrity of a liver of white rats at experimental toxic damage during various periods of ontogenesis. Global Veterinaria 2013; 11: 794-802. http://dx.doi.org/10.5829/idosi.gv.2013.11.6.82147
El-Gengaihi SE, Hassan EE, Hamed MA, Zahran HG, Mohammed MA. Chemical composition and biological evaluation of Physalis peruviana root as hepato-renal protective agent. Journal of Dietary Supplements 2013; 10: 39-53. http://dx.doi.org/10.3109/19390211.2012.760509
Dkhil MA, Al-Quraishy MS, Diab MS, Abdel Moneim AE. The potential protective role of Physalis peruviana L. fruit in cadmium-induced hepatotoxicity and nephrotoxicity. Food and Chemical Toxicology 2014; 47: 98-106. http://dx.doi.org/10.1016/j.fct.2014.09.013
Areshidze DA, Timchenko LD, Rzhepakovsky IV, Kozlova MA, Syomin IA, Piskov SI. Morphofunctional condition of hepatorenal system of rats at correction of the experimental CCl4-induced hepatorenal syndrome using an enzymatic hydrolyzate of Chlorophytum comosum L. Bothalia 2015; 45: 70-80.
Caglayan K, Gungor H, Cinar B, Avci B, Gur S, Arslan N. Effects of oleuropein on serum inflammatory cytokines and histopathological changes in rats with pancreatitis. Adv Clin Exp Med 2015; 24: 213-218. http://dx.doi.org/10.17219/acem/40453
Fan Q-L, Huang C-G, Jin Y, Feng B, Miao H-N, Li W-J, Jiao B-H, Yuan Q-S. Effects of shark hepatic stimulator substance on the function and antioxidant capacity of liver mitochondria in an animal model of acute liver injury. Acta Biochim Biophys Sin 2005; 37: 507-514. http://dx.doi.org/10.1111/j.1745-7270.2005.00081
Mobley CB, Toedebusch RG, Lockwood CM, Heese AJ, Zhu C, Krieger AE, Cruthirds CL, Hofheins JC, Company JM, Wiedmeyer CE, Kim DY, Booth FW, Roberts MD. Herbal adaptogens combined with protein fractions from bovine colostrum and hen egg yolk reduce liver TNF-? expression and protein carbonylation in Western diet feeding in rats. Nutrition & Metabolism 2014; 11: P. 1- http://dx.doi.org/10.1186/1743-7075-11-19
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright (c) 2015 D.A. Areshidze, L.D. Timchenko, M.A. Kozlova, I.A. Syomin, I.V. Rzhepakovsky, S.I. Piskov , V.N. Vakulin