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Abstract
The chronic diseases such as diabetes mellitus, metabolic syndrome and cardiovascular diseases have reached epidemic proportions in developed and developing countries. The high costs of the allopathic medicines represent a growing demand for non-allopathic alternatives. Curcuma longa is usually used as a spice in curries and as a dietary pigment and is considered a medicinal plant due important properties, with anti-inflammatory, anti-oxidant, anti-bacterial and anti-tumor action.The aim of this work was to evaluate the effects of Curcuma longa on the metabolic profile of Wistar rats treated with hyper caloric diet. Forty eight male rats were divided randomly into 4 groups (n=12) and treated for 40 days: G1 that received water (Control Group); G2 that received condensed milk solution ad libitum; G3 that received C. longa by gavage route and G4 that received condensed milk solution ad libitum and C. longa by gavage route. No significant differences for body weight and cholesterol were observed among the groups. Visceral fat, triglycerides and glycaemia were higher in the groups treated with condensed milk but did not differ when comparing G1 with G3 and G2 with G4. Analyzing our results it is possible to say that C. longa may not be efficient to promote benefits in lipid and glycemic profile as well as in the body weight and visceral fat of animals treated with hyper caloric diet.
References
Barbalho SM, Bueno PC, Delazari DS, Guiguer EL, Coqueiro DP, Araújo AC, de Souza Mda S, Farinazzi-Machado FM, Mendes CG, Groppo M. Antidiabetic and antilipidemic effects of Manilkara zapota. J Med Food 2015; 18(3): 385-91. http://dx.doi.org/10.1089/jmf.2013.0170
Sicras Mainar A, Navarro Artieda R, Ibáñez Nolla J.Economic Impact of Heart Failure According to the Effects of Kidney Failure. Rev Esp Cardiol 2014. pii: S0300-8932(14)00257-7. doi: 10.1016/j.recesp.2014.02.023.
Lewitt MS, Dent MS, Hall K. The Insulin-Like Growth Factor System in Obesity, Insulin Resistance and Type 2 Diabetes Mellitus. J Clin Med 2014; 3(4): 1561-74. http://dx.doi.org/10.3390/jcm3041561
Klafke JZ, Arnoldi da Silva M, Fortes Rossato M, Trevisan G, Banderó Walker CI, Martins Leal CA, Olschowsky Borges D, Chitolina Schetinger MR, Noal Moresco R, Medeiros Frescura Duarte MM, Soares Dos Santos AR, Nazário Viecili PR, Ferreira J. Antiplatelet, Antithrombotic, and Fibrinolytic Activities of Campomanesia xanthocarpa. Evid Based Complement Alternat Med 2012; 2012: 954748.
Jungbauer A, Medjakovic S. Anti-inflammatory properties of culinary herbs and spices that ameliorate the effects of metabolic syndrome. Maturitas 2012; 71: 227-239. http://dx.doi.org/10.1016/j.maturitas.2011.12.009
Opara EI, Chohan M. Culinary herbs and spices: their bioactive properties, the contribution of polyphenols and the challenges in deducing their true health benefits. Int J Mol Sci 2014; 15(10): 19183-202. http://dx.doi.org/10.3390/ijms151019183
Kumar S, Singh NN, Singh A, Singh N, Sinha RK. Use of Curcuma longa L. extract to stain various tissue samples for histological studies. Ayu 2014; 35(4): 447-51. http://dx.doi.org/10.4103/0974-8520.159027
Kumar A, Chetia H, Sharma S, Kabiraj D, Talukdar NC, Bora U. Curcumin Resource Database. Database (Oxford) 2015; 2015: bav070. doi: 10.1093/database/bav070. Print 2015.
Menon VP, Sudheer AAR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol 2007; 595: 105-125. http://dx.doi.org/10.1007/978-0-387-46401-5_3
Shishodia S, Chaturvedi MM, Aggarwal BB. Role of curcumin in cancer therapy. Curr Probl Cancer 2007; 31: 243-305. http://dx.doi.org/10.1016/j.currproblcancer.2007.04.001
Hatcher H, Planalp R, Cho J. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 2008; 65: 1631-1652. http://dx.doi.org/10.1007/s00018-008-7452-4
Bordoloi D, Roy NK, Monisha J, Ganesan P, Kunnumakkara AB. Multi-Targeted Agents in Cancer Cell Chemosensitization: What We Learnt from Curcumin Thus Far. Recent Pat Anticancer Drug Discov 2015.
Pawar RS, Toppo FA, Mandloi AS, Shaikh S. Exploring the role of curcumin containing ethanolic extract obtained from Curcuma longa (rhizomes) against retardation of wound healing process by aspirin. Indian J Pharmacol 2015; 47(2): 160-6. http://dx.doi.org/10.4103/0253-7613.153422
Gong C, Wu Q, Wang Y, Zhang D, Luo F, Zhao X. A biodegradable hydrogel system containing curcumin encapsulated in micelles for cutaneous wound healing. Biomaterials 2013; 34: 6377-87. http://dx.doi.org/10.1016/j.biomaterials.2013.05.005
American Diabetes Association. Standards of medical care in diabetes--2014. Diabetes Care 2014; 37(Suppl 1): S14-80. doi: 10.2337/dc14-S014.
Schulpis K, Karikas GA. Serum cholesterol and triglyceride distribution in 7767 school-aged Greek children. Pediatrics. 1998; 101(5): 861-4. http://dx.doi.org/10.1542/peds.101.5.861
Munshi RP, Joshi SG, Rane BN. Development of an experimental diet model in rats to study hyperlipidemia andinsulin resistance, markers for coronary heart disease. Indian J Pharmacol 2014; 46(3): 270-6. http://dx.doi.org/10.4103/0253-7613.132156
Wongcharoen W, Phrommintikul A.The protective role of curcumin in cardiovascular diseases. Int J Cardiol 2009; 133(2): 145-51. http://dx.doi.org/10.1016/j.ijcard.2009.01.073
Han JM, Lee JS, Kim HG, Seol IC, Im HJ, Cho JH, Son CG. Synergistic effects of artemisia iwayomogi and curcuma longa radix on High-fat diet-induced hyperlipidemia in a mouse model. J Ethnopharmacol 2015. pii: S0378-8741(15)30033-7. doi: 10.1016/j.jep.2015.07.021
Lin XL, Liu MH, Hu HJ, Feng HR, Fan XJ, Zou WW, Pan YQ, Hu XM, Wang Z. Curcumin Enhanced Cholesterol Efflux by Upregulating ABCA1 Expression Through AMPK-SIRT1-LXR? Signaling in THP-1 Macrophage-Derived Foam Cells. DNA Cell Biol 2015. http://dx.doi.org/10.1089/dna.2015.2866
Um MY, Hwang KH, Ahn J, Ha TY. Curcumin attenuates diet-induced hepatic steatosis by activating AMP-activated protein kinase. Basic Clin Pharmacol Toxicol 2013; 113(3): 152-7. http://dx.doi.org/10.1111/bcpt.12076
Sung Roh J, Lee H, Woo S, Yoon M, Kim J, Dong Park S, Shik Shin S, Yoon M. Herbal composition Gambigyeongsinhwan (4) from Curcuma longa, Alnus japonica, and Massa Medicata Fermentata inhibits lipid accumulation in 3T3-L1 cells and regulates obesity in Otsuka Long-Evans Tokushima Fatty rats. J Ethnopharmacol 2015; 171: 287-94. http://dx.doi.org/10.1016/j.jep.2015.05.056
Tranchida F, Shintu L, Rakotoniaina Z, Tchiakpe L, Deyris V, Hiol A, Caldarelli S. Metabolomic and Lipidomic Analysis of Serum Samples following Curcuma longaExtract Supplementation in High-Fructose and Saturated Fat Fed Rats. PLoS One 2015; 10(8): e0135948. http://dx.doi.org/10.1371/journal.pone.0135948
Lee MS, Wahlqvist ML, Chou YC, Fang WH, Lee JT, Kuan JC, Liu HY, Lu TM, Xiu L, Hsu CC, Andrews ZB, Pan WH. Turmeric improves post-prandial working memory in pre-diabetes independent of insulin. Asia Pac J Clin Nutr 2014; 23(4): 581-91. doi: 10.6133/apjcn.2014.23.4.24.
Nabavi SF, Thiagarajan R, Rastrelli L, Daglia M, Sobarzo-Sanchez E, Alinezhad H, Nabavi SM. Curcumin: a natural product for diabetes and its complications. Curr Top Med Chem 2015. http://dx.doi.org/10.2174/1568026615666150619142519
Li ZY, Ding LL, Li JM, Xu BL, Yang L, Bi KS, Wang ZT. H-NMR and MS based metabolomics study of the intervention effect of curcumin on hyperlipidemia mice induced by high-fat diet. PLoS One 2015; 10(3): e0120950. http://dx.doi.org/10.1371/journal.pone.0120950
Singh V, Jain M, Misra A, Khanna V, Prakash P, Malasoni R, Dwivedi AK, Dikshit M, Barthwal MK. Curcuma oil ameliorates insulin resistance & associated thrombotic complications in hamster & rat. Indian J Med Res 2015; 141(6): 823-32. http://dx.doi.org/10.4103/0971-5916.160719
Maradana MR, Thomas R, O'Sullivan BJ. Targeted delivery of curcumin for treating type 2 diabetes. Mol Nutr Food Res 2013; 57(9): 1550-6. http://dx.doi.org/10.1002/mnfr.201200791
Panahi Y, Khalili N, Hosseini MS, Abbasinazari M, Sahebkar A. Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: results of a randomized controlled trial. Complement Ther Med 2014; 22(5): 851-7. http://dx.doi.org/10.1016/j.ctim.2014.07.006
Shin HS, Han JM, Kim HG, Choi MK, Son CG, Yoo HR, Jo HK, Seol IC. Anti-atherosclerosis and hyperlipidemia effects of herbal mixture, Artemisia iwayomogi Kitamura and Curcuma longa Linne, in apolipoprotein E-deficient mice. J Ethnopharmacol 2014; 153(1): 142-50. http://dx.doi.org/10.1016/j.jep.2014.01.039
Al-Rubaei ZM, Mohammad TU, Ali LK. Effects of local curcumin on oxidative stress and total antioxidant capacity in vivo study. Pak J Biol Sci 2014; 17(12): 1237-41. http://dx.doi.org/10.3923/pjbs.2014.1237.1241
Kim Y, You Y, Yoon HG, Lee YH, Kim K, Lee J, Kim MS, Kim JC, Jun W. Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats. Food Chem 2014; 151: 148-53. http://dx.doi.org/10.1016/j.foodchem.2013.11.058
Dulbecco P, Savarino V. Therapeutic potential of curcumin in digestive diseases. World J Gastroenterol 2013; 19(48): 9256-70. http://dx.doi.org/10.3748/wjg.v19.i48.9256
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Copyright (c) 2015 Elen Landgraf Guiguer, Sandra Maria Barbalho, Adriano Cressoni Araújo, Maricelma da Silva Soares Souza, Patrícia Cincotto dos Santos Bueno, Claudemir Gregório Mendes, Sara da Silva Barbosa, Eliane Paschoal da Silveira , Daniel Pereira Coqueiro