Abstract
Helichrysum nudifolium is a valuable and well-known medicinal plant species in southern Africa. The current study critically reviewed the medicinal uses, phytochemistry and biological activities of H. nudifolium. Information on medicinal uses, phytochemistry and biological activities of H. nudifolium was collected from multiple internet sources which included Scopus, Google Scholar, Elsevier, Science Direct, Web of Science, Pubmed, SciFinder and BMC. Additional information was gathered from pre-electronic sources such as journal articles, scientific reports, theses, books and book chapters obtained from the University library. This study showed that H. nudifolium is mainly used as ethnoveterinary medicine, as colic and herbal medicine for fever, headache, swellings, infertility, pregnancy and postpartum problems. Pharmacological research revealed that H. nudifolium extracts have antibacterial, antimycobacterial, antifungal, anti-HIV, GABAA-benzodiazepine receptor-binding, anticancer, anti-inflammatory, antiplasmodial, antiprotozoal and cytotoxicity activities. There is need for experimental animal studies, randomized clinical trials and target-organ toxicity studies involving H. nudifolium crude extracts and compounds isolated from the species. Future should also focus on evaluation of pharmacological properties of compounds isolated from H. nudifolium.
References
Hilliard OM. Asteraceae. In Flora of Southern Africa, vol 33, part 7 (Inuleae), Leistner OA, Ed. Pretoria: Botanical Research Institute; 1983, pp. 1-39.
Beentje HJ. Compositae (part 2). In Flora of Tropical East Africa, Beentje HJ, Smith SAL, Eds. London: Crown Agents for Overseas Governments and Administration; 2002, pp. 1-315.
Germishuizen G, Meyer NL, et al. A checklist of South African plants. Pretoria: Southern African Botanical Diversity Network; 2006.
Williams VL, Balkwill K, Witkowski ETF. A lexicon of plants traded in the Witwatersrand umuthi shops. Bothalia 2001; 31(1): 71-98.
https://doi.org/10.4102/abc.v31i1.508
Botha J, Weiersbye IM. Ethnobotanic and forage uses of plants on mine properties in the Witwatersrand basin gold fields, South Africa. In Mine closure, Fourie A, Tibbett M, Wiertz J, Eds. Perth: Australian Centre for Geomechanics; 2010, pp. 325-342.
Van Wyk B-E, Oudtshoorn BV, Gericke N. Medicinal plants of South Africa. Pretoria: Briza Publications; 2013.
Moteetee A, Moffett RO, Seleteng-Kose L. A review of the ethnobotany of the Basotho of Lesotho and the Free State Province of South Africa (South Sotho). S Afr J Bot 2018.
https://doi.org/10.1016/j.sajb.2017.12.012
Reddy D. The phytochemistry and antimicrobial activity of selected indigenous Helichrysum species. MSc Dissertation. Johannesburg: University of the Witwatersrand; 2007.
Long C. Swaziland’s flora: siSwati names and uses. Swaziland National Trust Commission, Mbambane; 2005. Available from: http://www .sntc.org.sz/index.asp [Accessed 2 February 2019].
Van Wyk B-E, Gorelik B. The history and ethnobotany of Cape herbal teas. S Afr J Bot 2027; 110: 18-38.
https://doi.org/10.1016/j.sajb.2016.11.011
Van Wyk B-E. The potential of South African plants in the development of new food and beverage products. S Afr J Bot 2011; 77: 857-68.
https://doi.org/10.1016/j.sajb.2011.08.003
Watt JM, Breyer-Brandwijk MG. The medicinal and poisonous plants of southern and eastern Africa. London: E & S Livingstone; 1962.
Jacot Guillarmod A. Flora of Lesotho (Basutoland). Lehre: Cramer; 1971.
Sewani-Rusike CR, Mammen M. Medicinal plants used as home remedies: a family survey by first year medical students. Afr J Trad Compl Alt Med 2014; 11(5): 67-72.
http://dx.doi.org/10.4314/ajtcam.v11i5.11
Mathekga ADM. Antimicrobial activity of Helichrysum species and the isolation of a new phloroglucinol from Helichrysum caespititium. PhD dissertation. Pretoria: University of Pretoria; 2001.
Xaba PM. Helichrysum nudifolium (L.) Less; 2003. Available from: http://pza.sanbi.org/helichrysum-nudifolium [Accessed 12 February 2019].
Iwalewa EO, McGaw LJ, et al. Inflammation: the foundation of diseases and disorders. a review of phytomedicines of South African origin used to treat pain and inflammatory conditions. Afr J Biot 2007; 6(25): 2868-2885.
http://dx.doi.org/10.5897/AJB2007.000-2457
Seaman T. The antimicrobial and antimycobacterial activity of plants used for the treatment of respiratory ailments in Southern Africa and the isolation of anacardic acid from Ozoroa paniculosa. MSc Dissertation. Johannesburg: University of the Witwatersrand; 2005.
Fouche G, Cragg GM, et al. In vitro anticancer screening of South African plants. J Ethnopharmacol 2008; 119: 455-461.
http://dx.doi.org/10.1016/j.jep.2008.07.005
Van Wyk B-E. A review of Khoi-San and Cape Dutch medical ethnobotany. J Ethnopharmacol 2008; 119: 331–341.
http://dx.doi.org/10.1016/j.jep.2008.07.021
Semenya SS, Maroyi A. Data on medicinal plants used to treat respiratory infections and related symptoms in South Africa. Data Brief 2018; 21: 419-423.
http://dx.doi.org/10.1016/j.dib.2018.10.012
Bhat RB. Plants of Xhosa people in the Transkei region of Eastern Cape (South Africa) with major pharmacological and therapeutic properties. J Med Pl Res 2013; 7(20): 1474-1480.
http://dx.doi.org/10.5897/JMPR12.973
Heyman H. Identification of anti-HIV compounds in Helichrysum species (Asteraceae) by means of NMR-based metabolomics guided fractionation. PhD Thesis. Pretoria: University of Pretoria; 2013.
Rambuwani LD. Helichrysum nudifolium (L.) Less. var. pilosellum (L.f.) Beentje; 2009. Available from: http://pza.sanbi.org/helichrysum-nudifolium-var-pilosellum [Accessed 12 February 2019].
Meyer JJM, Lall N, Mathekga ADM. In vitro inhibition of drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis by Helichrysum caespititium. S Afr J Bot 2002; 68: 90-93.
https://doi.org/10.1016/S0254-6299(16)30462-8
Maroyi A. Diversity of use and local knowledge of wild and cultivated plants in the Eastern Cape province, South Africa. J Ethnobiol Ethnomed 2017; 13: 43.
https://doi.org/10.1186/s13002-017-0173-8
Erasto P, Adebola P, et al. An ethnobotanical study of plants used for the treatment of diabetes in the Eastern Cape Province, South Africa. Afr J Biot 2005; 4: 1458-1460.
https://doi.org/10.5897/AJB2005.000-3193
Mahop MT, Mayet M. En route to biopiracy? ethnobotanical research on anti diabetic medicinal plants in the Eastern Cape Province, South Africa. Afr J Biot 2007; 6(25): 2945-2952.
https://doi.org/10.5897/AJB2007.000-2436
Mudumbi JBN, Ntwampe SKO, et al. The role of pollutants in type 2 diabetes mellitus (T2DM) and their prospective impact on phytomedicinal treatment strategies. Environ Monit Assess 2018; 190: 262.
https://doi.org/10.1007/s10661-018-6634-2
Sabiu S, Madende M, et al. The scope of phytotherapy in southern African antidiabetic healthcare. Trans Royal Soc S Afr 2019.
https://doi.org/10.1080/0035919X.2019.1575927
Hutchings A, Van Staden J. Plants used for stress related ailments in traditional Zulu, Xhosa and Sotho medicine. part 1. plants used for headaches. J Ethnopharmacol 1994; 43: 89-124.
https://doi.org/10.1016/0378-8741(94)90008-6
Jäger AK, Hutchings A, Van Staden J. Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitors. J Ethnopharmacol 1996; 52: 95-100.
https://doi.org/10.1016/0378-8741(96)01395-5
Braithwaite MC. A laboratory model for studying inhalation therapy in traditional healing rites. MSc Dissertation. Johannesburg: University of the Witwatersrand; 2007.
Lamorde M, Tabuti JRS, et al. Medicinal plants used by traditional medicine practitioners for the treatment of HIV/AIDS and related conditions in Uganda. J Ethnopharmacol 2010; 130(1): 43-53.
https://doi.org/10.1016/j.jep.2010.04.004
Morris B. Chewa medical botany: a study of herbalism in southern Malawi. London: International African Institute; 1996.
Mabogo DEN. The ethnobotany of the Vhavenda. MSc dissertation. Pretoria: University of Pretoria; 1990.
Hutchings A, Johnson CT. Glimpses of a Xhosa herbal. Veld Flora 1986; 72: 59-62.
https://hdl.handle.net/10520/AJA00423203_2292
Hutchings A, Scott AH, et al. Zulu medicinal plants. Pietermaritzburg: Natal University Press; 1996.
Bohlmann F, Zdero C, et al. Neue diterpene und sesquiterpene aus Südafrikanischen Helichrysum-arten. Phytochem 1978; 17: 1917-1922.
https://doi.org/10.1016/S0031-9422(00)88733-6
Jakupovic J, Kuhnke J, et al. Phloroglucinol derivatives and other constituents from South African Helichrysum species. Phytochem 1986; 25(5): 1133-1142.
https://doi.org/10.1016/S0031-9422(00)81569-1
Reidel RVB, Cioni P, et al. Essential oil composition from three Helichrysum species. Planta Med 2016; 82(S 01): S1-S381.
https://doi.org/10.1055/s-0036-1596804
Lourens ACU, Van Vuuren SF, et al. Antimicrobial activity and in vitro cytotoxicity of selected South African Helichrysum species. S Afr J Bot 2011; 77: 229-235.
https://doi.org/10.1016/j.sajb.2010.05.006
Heyman HM. Metabolomic comparison of selected Helichrysum species to predict their antiviral properties. MSc dissertation. Pretoria: University of Pretoria; 2009.
Heyman HM, Senejoux F, et al. Identification of anti-HIV active dicaffeoylquinic- and tricaffeoylquinic acids in Helichrysum populifolium by NMR-based metabolomic guided fractionation. Fitoterapia 2015; 103: 155-164.
https://doi.org/10.1016/j.fitote.2015.03.024
Stafford GI, Jäger AK, Van Staden J. Activity of traditional South African sedative and potentially CNS-acting plants in the GABA-benzodiazepine receptor assay. J Ethnopharmacol 2005; 100: 210-215.
https://doi.org/10.1016/j.jep.2005.04.004
Clarkson C, Maharaj VJ, et al. In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa. J Ethnopharmacol 2004; 92: 177-191.
https://doi.org/10.1016/j.jep.2004.02.011
Mokoka TA, Zimmermann S, et al. In vitro screening of traditional South African malaria remedies against Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum. Planta Med 2011; 77: 1163-1667.
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