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Abstract
Antidesma laciniatum and A. membranaceum are small trees used as traditional medicines in tropical Africa. This extensive literature review synthesizes the information currently available on the medicinal uses, phytochemistry and biological activities of A. laciniatum and A. membranaceum. The university library and electronic search engines such as Google Scholar, Scopus, Web of Science, ScienceDirect, and PubMed were searched for pertinent information on the medicinal uses, phytochemistry, and biological activities of A. laciniatum and A. membranaceum. Traditionally, the species have been used as aphrodisiac, and traditional medicine for cough, kwashiorkor, mouth ulcers, pneumonia, prevent miscarriage, snakebites, stomachache and wounds. Various phytochemicals such as essential oils, isoflavonoid glycosides, phytosterols, benzopyranones, lignin glucosides, megastigmane, phenolics, steroids, squalene, terpenoids, triterpenoids, and tetrahydroisoquinoline alkaloids have been isolated from A. laciniatum and A. membranaceum. In vitro studies have confirmed the biological activities of A. laciniatum and A. membranaceum which, include antimicrobial, antioxidant, antiplasmodial, antitrypanosomal, leishmanicidal, molluscicidal and cytotoxicity activities. More pharmacological studies including phytochemical, toxicological, in vitro and in vivo experiments are needed to provide evidence for the clinical effectiveness of remedies prepared from the species.
References
Kumaran A, Karunakaran RJ. In vitro antioxidant activities of methanol extracts of five Phyllanthus species from India. LWT Food Sci Technol 2007; 40: 344-52.
https://doi.org/10.1016/j.lwt.2005.09.011
Ramasamy S, et al. Cytotoxicity evaluation of five selected Malaysian Phyllanthaceae species on various human cancer cell lines. J Med Plants Res 2011; 5(11): 2267-73.
Sarin B, et al. An overview of important ethnomedicinal herbs of Phyllanthus species: Present status and future prospects. Sci World J 2014, article ID 839172.
https://doi.org/10.1155/2014/839172
Geethangili M, Ding S-T. A review of the phytochemistry and pharmacology of Phyllanthus urinaria L. Front Pharmacol 2018; 9: 1109.
https://doi.org/10.3389/fphar.2018.01109
Calixto JB, et al. A review of the plants of the genus Phyllanthus: Their chemistry, pharmacology and therapeutic potential. Med Res Rev 1998; 18(4): 225-58.
https://doi.org/10.1002/(SICI)1098-1128(199807)18:4<225::AID-MED2>3.0.CO;2-X
Harish R, Shivanandappa T. Antioxidant activity and hepatoproctective potential of Phyllanthus niruri. Food Chem 2006; 93: 180-5.
https://doi.org/10.1016/j.foodchem.2004.11.049
Jagessar RC, Mars A, Gomes G. Selective antimicrobial properties of Phyllanthus acidus leaf extract against Candida albicans, Escherichia coli and Staphylococcus aureus using stokes disc diffusion, well diffusion, streak plate and a dilution method. Nat Sci 2008; 6(2): 24-38.
Sabir SM, Rocha JBT. Water-extractable phytochemicals from Phyllanthus niruri exhibit distinct in vitro antioxidant and in vivo hepatoprotective activity against paracetamol-induced liver damage in mice. Food Chem 2008; 111(4): 845-51.
https://doi.org/10.1016/j.foodchem.2008.04.060
Leeya Y, et al. Hypotensive activity of an n-butanol extract and their purified compounds from leaves of Phyllanthus acidus (L.) Skeels in rats. Eur J Pharmacol 2010; 649: 301-13.
https://doi.org/10.1016/j.ejphar.2010.09.038
Burkill HM. The useful plant of west tropical African. Richmond: Royal Botanic Gardens, Kew; 1985.
Lovett JC, et al. Field guide to the moist forest trees of Tanzania. York: University of York; 2007.
Mahomoodally MF, Korumtollee HN, Chady ZZBK. Ethnopharmacological uses of Antidesma madagascariense Lam. (Euphorbiaceae). J Intercult Ethnopharmacol 2015; 4(1): 86-9.
https://doi.org/10.5455/jice.20141202055655
Schmelzer GH. Antidesma membranaceum Müll. Arg. In Schmelzer GH, Gurib-Fakim A (Eds.), Plant resources of tropical Africa 11: Medicinal plants 1. Leiden: Backhuys Publishers; 2008, pp. 103-4.
Carter S, Radcliffe-Smith A. Euphorbiaceae part 2. In Polhill RM (Ed.), Flora of tropical east Africa. Rotterdam: AA Balkema; 1988, pp. 409-597.
Fonge BA, Tchetcha DJ, Nkembi L. Diversity, distribution, and abundance of plants in Lewoh-Lebang in the Lebialem highlands of southwestern Cameroon. Int J Biod 2013, article ID 642579.
https://doi.org/10.1155/2013/642579
Sonké B, Couvreur T. Tree diversity of the Dja Faunal Reserve, southeastern Cameroon. Biod Data J 2014; 2: e1049.
https://doi.org/10.3897/BDJ.2.e1049
Radcliffe-Smith A. Euphorbiaceae, subfamilies Phyllantoideae, Oldfieldioideae, Acalyphoideae, Crotonoideae and Euphorbioideae, tribe Hippomaneae. In Pope GV (Ed.), Flora Zambesiaca volume 9 part 4. Richmond: Royal Botanic Gardens, Kew; 1996, pp. 1-337.
Palgrave MC. Keith Coates Palgrave trees of southern Africa. Cape Town: Struik Publishers; 2002.
Greenway PJ, et al. The vegetation of Mafia Island, Tanzania. Kirkia 1988; 13(1): 197-238.
Louppe D, Oattara N, Coulibaly A. The effects of brush fires on vegetation: the Aubréville fire plots after 60 years. Commonwealth For Rev 1995; 74(4): 288-92.
Sunderland TCH, et al. Vegetation assessment of Takamanda Forest Reserve, Cameroon. In Comiskey JA, Sunderland TCH, Sunderland-Groves JL (Editors), Takam-anda: The biodiversity of an African rainforest. Washington DC: Smithsonian Institution, SI/MAB series no. 8; 2003.
Akoègninou A, Van der Burg WJ, Van der Maesen LJG. Flore analytique du Bénin. Leiden: Backhuys Publishers; 2006.
Strugnell AM. A checklist of the Spermatophytes of Mt. Mulanje, Malawi. Scripta Bot Belgica 2006; 34: 1-199.
Catarino L, et al. An annotated checklist of the vascular flora of Guinea-Bissau, West Africa. Blumea 2008; 53: 1-222.
https://doi.org/10.3767/000651908X608179
Figueiredo E, Smith GF. Plants of Angola. Pretoria: Strelitzia 22, South African National Biodiversity Institute; 2008.
Figueiredo E, et al. Annotated catalogue of the flowering plants of São Tomé and Príncipe. Bothalia 2011; 41(1): 41-82.
https://doi.org/10.4102/abc.v41i1.34
Brundu G, Camarda I. The Flora of Chad: A checklist and brief analysis. PhytoKeys 2013; 23: 1-18.
https://doi.org/10.3897/phytokeys.23.4752
Darbyshire I, et al. The plants of Sudan and South Sudan. London: Kew publishing, Royal Botanic Gardens, Kew; 2015.
Adjossou K, et al. Forest land use and native trees diversity conservation in Togolese mega hotspot, Upper Guinean, West Africa. J Ecol Nat Environ 2019; 11(9): 127-42.
https://doi.org/10.5897/JENE2019.0799
Chhabra SC, Mahunnah RLA, Mshiu EN. Plants used in traditional medicine in eastern Tanzania. VI. Angiosperms (Sapotaceae to Zingiberaceae). J Ethnopharmacol 1993; 39: 83-103.
https://doi.org/10.1016/0378-8741(93)90024-Y
Hutchinson J, Dalziel JM. Flora of west tropical Africa vol 1 part 2. London: Crown Agents; 1958.
Vasileva B. Plantes Medicinales de Guinee. Moscow: University of Moscow; 1969.
Boyom FF, et al. Aromatic plants of tropical central Africa. Part XLII. Volatile components from Antidesma laciniatum Muell. Arg. var. laciniatum growing in Cameroon. Flavour Fragr J 2003; 18: 451-3.
https://doi.org/10.1002/ffj.1251
Lautenschläger T, et al. First large-scale ethnobotanical survey in the province of Uíge, northern Angola. J Ethnobiol Ethnomed 2018; 14: 51.
https://doi.org/10.1186/s13002-018-0238-3
Ndah NR, et al. Ethnobotanical study of commonly used medicinal plants of the Takamanda rainforest south west, Cameroon. Afr J Plant Sci 2013; 7(1): 21-34.
https://doi.org/10.5897/AJPS12.111
Neuwinger HD. Plants used for poison fishing in tropical Africa. Toxicon 2004; 44: 417-30.
https://doi.org/10.1016/j.toxicon.2004.05.014
Mbayo KM, et al. Contribution to ethnobotanical knowledge of some Euphorbiaceae used in traditional medicine in Lubumbashi and its surroundings (DRC). J Adv Bot Zool 2016; 4(2): 1-16.
Cooper GP, Samuel JR. The Evergreen Forests of Liberia: A report on investigations made in the west African Republic of Liberia by the Yale University School of Forestry in Cooperation with the Firestone Plantations Company. Connectcut: Yale School of Forestry Bulletin 31; 1931.
Gelfand M, et al. The traditional medical practitioner in Zimbabwe: His principles of practice and pharmacopoeia. Gweru: Mambo Press; 1985.
Latham P. Edible caterpillars and their food plants in Bas-Congo province, Democratic Republic of Congo. London: Department for International Development; 2015.
Choi CW, et al. Antiproliferation effects of selected Tanzania plants. Afr J Trad Compl Alt Med 2015; 12(2): 96-102.
https://doi.org/10.4314/ajtcam.v12i2.15
K’Okul RNO. Maternal and child health in Kenya: A study of poverty, disease and malnutrition in Samia. Uppsala: Scandinavian Institute of African Studies; 1991.
Kokwaro JO. Medicinal plants of East Africa. Nairobi: University of Nairobi Press; 2009.
Dalziel JM. The useful plants of west tropical Africa. London: The Crown Agents for the Colonies; 1948.
Quattrocchi U. CRC world dictionary of medicinal and poisonous plants: common names, scientific names, eponyms, synonyms, and etymology. London: CRC Press; 2012.
Iwu MM. Handbook of African medicinal plants. Boca Raton: CRC Press; 2014.
https://doi.org/10.1201/b16292
Boyom FF, et al. Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants. Phytochem 2003; 64: 1269-75.
https://doi.org/10.1016/j.phytochem.2003.08.004
Tchinda AT, et al. Squalene and amentoflavone from Antidesma laciniatum. Bull Chem Soc Ethiopia 2006; 20(2): 325-8.
https://doi.org/10.4314/bcse.v20i2.61417
Djouossi MG, et al. Chevalierinoside B and C: Two new isoflavonoid glycosides from the stem bark of Antidesma laciniatum Muell. Arg (syn. Antidesma chevalieri Beille). Phytochem Lett 2014; 9: 149-52.
https://doi.org/10.1016/j.phytol.2014.05.013
Djouossi MG, et al. Chevalierinoside A: a new isoflavonoid glycoside from the stem bark of Antidesma chevalieri Beille (Euphorbiaceae). Bull Chem Soc Ethiopia 2014; 28: 309-14.
https://doi.org/10.4314/bcse.v28i2.16
Buske A, et al. Benzopyranones and ferulic acid derivatives from Antidesma membranaceum. Phytochem 1997; 46(8): 1385-8.
https://doi.org/10.1016/S0031-9422(97)00488-3
Buske A, et al. Antidesmone, a novel type isoquinoline alkaloid from Antidesma membranaceum (Euphorbiaceae). Tetrahedron 1999; 55(4): 1079-86.
https://doi.org/10.1016/S0040-4020(98)01107-7
Bringmann G, et al. Biosynthesis of antidesmone in cell cultures of Antidesma membranaceum (Euphorbiaceae): an unprecedented class of glycine-derived alkaloids. J American Chem Soc 2000; 122(41): 9905-10.
https://doi.org/10.1021/ja001391k
Bringmann G, et al. Antidesmone, a novel antitrypanosomal alkaloid. Pharmaceut Pharmacol Lett 2001; 11(2): 47-8.
Buske A, et al. Alkaloidal, megastigmane and lignan glucosides from Antidesma membranaceum (Euphorbiaceae). European J Org Chem 2001; 18: 3537-43.
https://doi.org/10.1002/1099-0690(200109)2001:18<3537::AID-EJOC3537>3.0.CO;2-A
Magadula JJ, et al. Anti-Mycobacterial and toxicity activities of some priority medicinal plants from Lake Victoria basin, Tanzania. European J Med Plants 2012; 2(2): 125-31.
https://doi.org/10.9734/EJMP/2012/739
Ogunlana EO, Ramstad E. Investigations into the antibacterial activities of local plants. Pl Med 1975; 27: 354.
https://doi.org/10.1055/s-0028-1097814
Adewunmi CO, Sofowora EA. Preliminary screening of some plant extracts for molluscicidal activity. Pl Med 1980; 39: 57-65.
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