Anthropometry and Liver Function Parameters in Individuals with Metabolic Syndrome
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Keywords

Metabolic syndrome
non-alcoholic fatty liver disease
high-density lipoprotein cholesterol
liver enzymes

How to Cite

Aladejana, A. E., & Aladejana, E. B. (2021). Anthropometry and Liver Function Parameters in Individuals with Metabolic Syndrome . Journal of Pharmacy and Nutrition Sciences, 11, 151–163. https://doi.org/10.29169/1927-5951.2021.11.18

Abstract

Metabolic syndrome (MS) is a metabolic condition commonly associated with central adiposity and altered liver function parameters (LFPs). Several studies have suggested these altered LFPs as a result of fatty liver diseases (e.g., non-alcoholic fatty liver diseases) often prevalent in MS. Since altered LFPs are very common in MS, there is a possibility they can be used as predictors of MS. However, only a few studies have been carried out to evaluate this possibility. This study, therefore, aimed to evaluate the potential of LFPs as predictors or risk factors of MS. The study groups included 50 individuals diagnosed with MS (case group) and 50 apparently normal individuals (control) from Ibadan, Oyo State, Nigeria. Anthropometric measurements, phlebotomy, liver function tests, and lipid profile estimations were done using standard procedures. (The result and conclusion section has been omitted).

https://doi.org/10.29169/1927-5951.2021.11.18
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References

Kim HR, Han MA. Association between serum liver enzymes and metabolic syndrome in Korean adults. Int J Environ Res Public Health 2018; 15(8). https://doi.org/10.3390/ijerph15081658

Lam DW, LeRoith D. Metabolic syndrome. Lege artis - Das Mag zur ärztlichen Weiterbildung 2019; 4(05): 1-21.

Sajithya Perera, Lohsoonthorn V, Jiamjarasrangsi W, Lertmaharit S, Williams MA. Association Between Elevated Liver Enzymes and Metabolic Syndrome Among Thai Adults. Natl Inst Heal [Internet] 2008; 2(3): 171-8. https://doi.org/10.1016/j.dsx.2008.04.012

Al-Sultan AI. Assessment of the relationship of hepatic enzymes with obesity and insulin resistance in adults in Saudi Arabia. Sultan Qaboos Univ Med J 2008; 8(2): 185-92.

Khan AR, Awan FR, Najam SS, Islam M, Siddique T, Zain M. Elevated serum level of human alkaline phosphatase in obesity. J Pak Med Assoc 2015; 65(11): 1182-5.

Giannini EG, Testa R, Savarino V. Liver enzyme alteration: A guide for clinicians. Cmaj 2005; 172(3): 367-79. https://doi.org/10.1503/cmaj.1040752

Thompson J. Plasma protein tests: how to interpret abnormal results. Guidel Pract [Internet] 2018; 452(2): 1-12. Available from: https://www.guidelinesinpractice.co.uk/liver-disease/plasma-protein-tests-how-to-interpret-abnormal-results/454286.article

Cho HM, Kim HC, Lee JM, Oh SM, Choi DP, Suh I. The association between serum albumin levels and metabolic syndrome in a rural population of Korea. J Prev Med Public Heal 2012; 45(2): 98-104. https://doi.org/10.3961/jpmph.2012.45.2.98

Koga M, Otsuki M, Matsumoto S, Saito H, Mukai M, Kasayama S. Negative association of obesity and its related chronic inflammation with serum glycated albumin but not glycated hemoglobin levels. Clin Chim Acta 2007; 378(1-2): 48-52. https://doi.org/10.1016/j.cca.2006.10.013

Nishimura R, Kanda A, Sano H, Matsudaira T, Miyashita Y, Morimoto A, et al. Glycated albumin is low in obese, non-diabetic children. Diabetes Res Clin Pract 2006; 71(3): 334-8. https://doi.org/10.1016/j.diabres.2005.07.008

Ko SH, Baeg MK, Han K Do, Ko SH, Ahn YB. Increased liver markers are associated with higher risk of type 2 diabetes. World J Gastroenterol 2015; 21(24): 7478-87. https://doi.org/10.3748/wjg.v21.i24.7478

Alberti KGMM, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: A joint interim statement of the international diabetes federation task force on epidemiology and prevention; National heart, lung, and blood institute; American heart association; World heart federation; International Circulation 2009; 120(16): 1640-5. https://doi.org/10.1161/CIRCULATIONAHA.109.192644

Kälsch J, Bechmann LP, Heider D, Best J, Manka P, Kälsch H, et al. Normal liver enzymes are correlated with severity of metabolic syndrome in a large population based cohort. Sci Rep [Internet] 2015; 5(April): 1-9. https://doi.org/10.1038/srep13058

Hampe CS, Shaffer ML, Roth CL. Associations between Liver Enzyme Levels and Parameters of the Metabolic Syndrome in Obese Children. Horm Res Paediatr 2017; 88(3-4): 265-73. https://doi.org/10.1159/000479868

Adegoke OA, Adedoyin RA, Balogun MO, Adebayo RA, Bisiriyu LA, Salawu AA. Prevalence of Metabolic Syndrome in a Rural Community in Nigeria. Metab Syndr Relat Disord 2010; 8(1): 59-62. https://doi.org/10.1089/met.2009.0037

Charles-Davies MA, Fasanmade AA, Olaniyi JA, Oyewole OE, Owolabi MO, Adebusuyi JR, et al. Metabolic alterations in different stages of hypertension in an apparently healthy Nigerian population. Int J Hypertens 2013; 2013. https://doi.org/10.1155/2013/351357

Khashayar P, Heshmat R, Qorbani M, Motlagh ME, Aminaee T, Ardalan G, et al. Metabolic syndrome and cardiovascular risk factors in a national sample of adolescent population in the middle east and north africa: The CASPIAN III study. Int J Endocrinol 2013; 2013. https://doi.org/10.1155/2013/702095

De Onis M, Habicht J-P. Anthropometric reference data for international use : recommendations from a World Health Organization Expert COmmittee1 ” 3. Am J Clin Nutr 1996; 64(4): 650-8. https://doi.org/10.1093/ajcn/64.4.650

Vicente-Rodríguez G, Rey-López JP, Mesana MI, Poortvliet E, Ortega FB, Polito A, et al. Reliability and intermethod agreement for body fat assessment among two field and two laboratory methods in adolescents. Obesity [Internet] 2012; 20(1): 221-8. https://doi.org/10.1038/oby.2011.272

Freedman DS, Thornton JC, Pi-Sunyer FX, Heymsfield SB, Wang J, Pierson RN, et al. The body adiposity index (Hip Circumference ÷ Height 1.5) Is not a more accurate measure of adiposity than Is BMI, waist circumference, or hip circumference. Obesity 2012; 20(12): 2438-44. https://doi.org/10.1038/oby.2012.81

Emam H, Ahmed E, Abdel-Daim M. Antioxidant capacity of omega-3-fatty acids and vitamin E against imidacloprid-induced hepatotoxicity in Japanese quails. Environ Sci Pollut Res 2018; 25(12): 11694-702. https://doi.org/10.1007/s11356-018-1481-9

Obi FO, Omogbai LA, Oriafo OSJ, Ovat OD. Effect of a Short Time Post Carbon Tetrachloride Treatment Interval on Rat Plasma Enzyme Levels and Percentage Mortality. J Appl Sci Environ 2001; 5(1): 5-8. https://doi.org/10.4314/jasem.v5i1.54930

Roy AS, Bandyopadhyay A. Effect of ramadan intermittent fasting on haematological parameters, lipid profile and renal markers in young muslim males of Kolkata, India. Indian J Physiol Pharmacol 2017; 61(4): 361-7.

Sani Ibrahim, Aliyu Umar R, Hassan SW, Faruq UZ, Bello F, Aminu H, et al. Hepatoprotective Effect of Azadirachta indica Leaf Fractionated Extracts against Snake Venom Toxicity on Albino Rats. Saudi J Biomed Res 2020; 5(6): 112-7. https://doi.org/10.36348/sjbr.2020.v05i06.004

Godoy-Matos AF, Silva Júnior WS, Valerio CM. NAFLD as a continuum: From obesity to metabolic syndrome and diabetes. Diabetol Metab Syndr [Internet] 2020; 12(1): 1-20. https://doi.org/10.1186/s13098-020-00570-y

Adams LA, Knuiman MW, Divitini ML, Olynyk JK. Body mass index is a stronger predictor of alanine aminotransaminase levels than alcohol consumption. J Gastroenterol Hepatol 2008; 23(7 PT1): 1089-93. https://doi.org/10.1111/j.1440-1746.2008.05451.x

Ioannou GN, Weiss NS, Boyko EJ, Kowdley K V., Kahn SE, Carithers RL, et al. Is central obesity associated with cirrhosis-related death or hospitalization? A population-based, cohort study. Clin Gastroenterol Hepatol 2005; 3(1): 67-74. https://doi.org/10.1016/S1542-3565(04)00442-2

Stranges S, Dorn JM, Muti P, Freudenheim JL, Farinaro E, Russell M, et al. Body Fat Distribution, Relative Weight, and Liver Enzyme Levels: A Population-Based Study. Hepatology 2004; 39(3): 754-63. https://doi.org/10.1002/hep.20149

Busher JT. Serum Albumin and Globulin. Clin Methods Hist Phys Lab Exam [Internet] 1990; Available from: http://www.ncbi.nlm.nih.gov/pubmed/21250048

Lin D, Bridgeman MB, Brunetti L. Evaluation of alterations in serum immunoglobulin concentrations in components of metabolic syndrome, obesity, diabetes, and dyslipidemia. BMC Cardiovasc Disord 2019; 19: 1-6. https://doi.org/10.1186/s12872-019-01296-0

Gerunov T V, Shitikov V V, Tarasenko AA, Gerunova LK. Correlations of biochemical parameters of blood serum in swine during anti-parasitic treatment with Ivermin followed by pharmacocorrection. Int Conf World Technol Trends Agribus 2021. https://doi.org/10.1088/1755-1315/624/1/012224

Ghosh S, Suryawanshi SA. Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Indian J Exp Biol 2001; 39(8): 748-59.

Rocha VZ, Santos RD. Cholesterol and inflammation: The lesser the better in atherothrombosis. Eur J Prev Cardiol 2018; 25(9): 944-7. https://doi.org/10.1177/2047487318772936

DerSarkissian C. What is a total protein test ? Highlights protein test. WebMD 2017. p. 1-9.

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