Keywords
gamma-linolenic acid
cholesterol
triglycerides
blood glucose
How to Cite
Abstract
Weight reducing effect of Evening primrose oil in healthy rabbits was assessed following administration of EPO for 60 days in the doses of 90, 180 and 360 ul/Kg. Reduction in weight might be due to significant decrease in cholesterol, triglycerides, LDL-C, blood glucose and increase in HDL-C.
References
Al-Shabanah, OA. 1997. Effect of evening primrose oil on gastric ulceration and secretion induced by various ulcerogenic and necrotizing agents in rats. Food and Chemical Toxicology. 35: 769-775.
Hanyz, I. Pienkowska, H. Dudkowiak, A. and Frackowiak, D. 2006. The photochemical stability of oil from Evening primrose oil seeds. Dyes and pigments. 70: 177-184.
Arimura, T. Kojima-Yuasa, A. Suzuki, M. Kennedy, DO. and Matsui-Yuasa, I. 2003. Caspase-independent apoptosis induced by evening primrose oil extract in Ehrlich ascites tumor cells. Cancer Lett. 201: 9-16.
Jelinska, M. Tokarz, A. Regina, O. and Czorniuk-Sliwa, A. 2003. Effects of dietary linseed, evening primrose oil or fish oils in fatty acid and prostaglandin E2 contents in the rat livers and 7, 12-dimethylbenz[a]anthracene-induced tumours. Biochimica et Biophysica Acta. 1637: 193-199.
Senanayake, SPJN. and Shahidi, F. 2004. Incorporation of docosahexaenoic acid (DHA) into evening primrose oil (Oenothera biennis L.) oil via lipase-catalyzed transesterification. Food Chemistry. 85: 489-496.
Peiretti, BAPG. Palmegiano, GB. and Masoero, G. 2004. Chemical composition, organic matter digestibility and fatty acid content of evening primrose (Oenothera paradoxa) during its growth cycle. Animal Feed Science and Technology. 116: 293-299.
McFarlin, BLM. Gibson, MH. O’Rear, J. and Harman, P. 1999. A National survey of herbal prepration use by Nursemidwives for labor stimulation. Journal of Nurse-Midwifery. 44: 205-216.
Shotton, HR. Broadbent, S. and Lincoln, J. 2004. Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with α-lipoic acid and evening primrose oil, Autonomic Neuroscience: Basic and Clinical. 111: 57-65.
Balasinska, B. 1998. Hypocholesterolemic effect of dietary evening primrose oil (Oenothera paradoxa) cake extract in rats. Food Chemistry. 63: 453-459.
Fieldsend, AF. and Morison, JIL. 2000. Climatic conditions during seed growth significantly influence oil content and quality in winter and spring evening primrose crops (Oenothera spp.). Industrial Crops and Products. 12: 137- 147.
Woltil, HA. Beusekom, C.Mv. Schaafsma, A. Okken, A. and Muskiet, FAJ. 1999. Does supplementation of formula with evening primrose oil and fish oils augment long chain polyunsaturated fatty acid status of low birthweight infants to that of breast-fed counterparts?. Prostaglandins, Leukotrienes and Essential Fatty Acids. 60: 199-208.
Keegan, A. Cotter, MA. and Cameron, NE. 2001. Corpus cavernosum dysfunction in diabetic rats: effects of combined α-lipoic acid and γ-linolenic acid treatment. Diabetes / Metab. Research Review. 17: 380-386.
Jack, AM. Keegan, A. Cotter, MA. and Cameron, NE. 2002. Effect of diabetes and evening primrose oil treatment responses of aorta, corpus cavernosum and mesenteric vasculature in rats. Life science. 71: 1863-1877.
Julu, PO. Gow, JW. and Jamal, GA. 1996. Endogenous cycle-oxygenase substrates mediate the neuroactivity of evening primrose oil in rats. Journal of Lipid mediators and cell signaling. 13: 115-125.
Fang, C. Jiang, Z. and Tomlinson, DR. 1997. Expression of constitutive cyclooxygenase (COX.l) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels. Prostaglandins Leukotrienes and Essential Fatty Acids. 56: 157-63.
Hassig, A. Liang, WX. and Stampfli, K. 2000. Bronchial asthma: information on phytotherapy with essential fatty acids. Medical Hypotheses. 54: 72-74.
Ford, I. Cotter, MA. Cameron, NE. and Greaves, M. 2001. The effects of treatment with α-lipoic acid or evening primrose oil on vascular haemostatic and lipid risk factors, blood flow, and peripheral nerve conduction in the streptozotocin-diabetic rat. Metabolism. 50: 868-875.
Riaz, A. Khan, RA. and Ahmed, SP. 2009. Assessment of anticoagulant effect of evening primrose oil. Pak J.Pharm.Sci. 22: 355-359.
Peterson, LD. Thies, F. and Calder, PC. 1999. Dosedependent effects of dietary γ -linolenic acid on rat spleen lymphocyte functions. Prostaglandins, Leukotrienes and Essential Fatty Acids. 61: 19-24.
Furse, RK. Rossetti, RG. and Seiler, CM. 2001. Oral administration of γ -linolenic acid, an unsaturated fatty acid with anti-inflammatory properties, modulates interleukin- 1beta production by human monocytes. J Clin Immunol. 22: 83-91.
Furse, RK. Rossetti, RG. and Zurier, RB. 2002. Gammalinolenic acid, an unsaturated fatty acid with antiinflammatory properties, blocks amplification of IL-1 beta production by human monocytes. J Immunol. 167: 490-496.
Kehveci, A. Bayark, F. Mutlu, B. Emre, Y. Karrahmet, T. Tigen, K. and Basaran, Y. 2008. Clinical significance of High- Density Lipoprotien cholesterol in Left-sided Infective Endocarditis. Am J. Cardiol. 101: 1170-1173.
Wegge, JK. Roberts, CK. Ngo, TH. and Barnard, RJ. 2004. Effect of diet and exercise intervention on inflammatory and adhesion molecules in postmenopausal women on hormone replacement therapy and at risk for Coronary Artery Disease. Metabolism. 53: 377-381.
Vazquez, R.de La P. Dominguez, EM. Perona, JS. and RGutierrez, V. 2004. Effects of different dietary oils on inflammatory mediator generation and fatty acid composition in rat neutrophils. Metabolism. 53: 59-65.
Khan, MA. and Shahidi, F. 2002. Photooxidative stability of stripped and non-stripped borage and evening primrose oil and their emulsions in water. Food Chemistry. 79: 47-53.
Landbo, AK. and Meyer, AS. 2001. Enzyme-assisted extraction of anti-oxidative phenols from black currant juice press residues, Ribes nigram. J. Agric. Food Chem. 49: 3169-3177.
Lapenna, D. Pierdomenico, SD, Ciofani, G. Giamberardino, MA. and Cuccurullo, F. 2004. Aortic glutathione metabolic status: time dependent alteration in fat-fed rabbits. Atherosclerosis. 173: 19-25.
Puri, BK. 2004. The clinical advantages of cold-pressed nonraffinated evening primrose oil over refine preparations. Medical hypotheses. 62: 116-118.
Peschel, W. Dieckmann, W. Sonnenschein, M. and Plescher, A. 2007. High antioxidant potential of pressing residues from evening primrose oil in comparison to other oilseed cakes and plant antioxidants. Industrial crops and products. 25: 44- 54.
Dirks, J. Aswegen, CHV. and Plessis, DJ. 1998. Cytokine levels affected by γ -linolenic acid. Prostaglandins, Leukotrienes and Essential Fatty Acids. 59: 273-277.
Ghasemnezhad, A. and Honermeier, B. 2007. Seed yield, oil content and fatty acid composition of oenothera biennis L. affected by harvest date and harvest method. Industrial Crops and Products. 25: 274-281.
Dines, KC. Cotter, MA. and Cameron, NE. 1996. Effectiveness of natural oils as sources of γ-linolenic acid to correct peripheral nerve conduction velocity abnormalities in diabetic rats: modulation by thromboxane A2 inhibition. Prostaglandins, Leukotrienes and Essential Fatty Acids. 55: 159-165.
Engler, MM. and Engler, MB. 1998. The effects of dietary evening primrose, black currant, borage and fungal oils in plasma, hepatic and vascular tissue fatty acid composition in the spontaneously hypertensive rat. Nutrition Research. 18: 1533-1544.
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