Keywords
programmed cell death
apoptosis
autophagy
necroptosis
synthetic Bile Acids
How to Cite
Abstract
Bile Acids (BAs) possess a considerably significant part in the form of emulsifiers in digestion besides absorption of dietary lipids. BAs represent amphiphilic molecules, that are primary metabolites formed from cholesterol by the aid of enzymes acting on cholesterol. Earlier BAs were believed to be tumor repressors. The tumor repressive actions of BAs are correlated with programmed cell death (PCD). Furthermore, dependent on this observation different Synthetic BAs products have been generated along with their utilization regarding induction of PCD (in the form of apoptosis, autophagy or necroptosis in variable kinds of human cancers. Thus we conducted a narrative review till August 2022. The present article might form the basis of generationof such innovative therapies even for cancers/tumors that are cisplatin resistant. With time these therapies might be used for the treatment of neurodegenerative diseases (NDD), amyotrophic sclerosis, and numerous metabolic and haematological diseases as described for use of TUDCA.
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Kaur KK. Delivered a talk on 30th September on 'Advantages and Limitations of utilizing Clostridium species as Probiotics-ASytematic Review'' in a webinar held by Gastroenterology conference on 30th September 2021.
Kaur KK, Allahbadia GN, Singh M. Utilization of Clostridium Species as Probiotics as an Alternative to the Conventional Probiotics like Lactobacillus rhamnosus /Bifidobacterium-How Far is it Feasible-A Systematic Review. J Endocrinol-2021; 5(1): 1-12.
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