Benthaminin 3, a Novel Antibacterial Cassane-Type Furanoditerpenoid from Caesalpinia benthamiana
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Keywords

 Caesalpinia benthamiana (Baill.) Herend. and Zarucchi, Mezoneuron benthamianum Baill, Caesalpinaceae, Cassane-type furanoditerpenoids, Antibacterial activities.

How to Cite

Rita A. Dickson, Kofi Annan, Theophilus C. Fleischer, & Peter J. Houghton. (2012). Benthaminin 3, a Novel Antibacterial Cassane-Type Furanoditerpenoid from Caesalpinia benthamiana . Journal of Pharmacy and Nutrition Sciences, 2(1), 20–25. https://doi.org/10.6000/1927-5951.2012.02.01.3

Abstract

The roots of Caesalpinia benthamiana (synonym. Mezoneuron benthamianum)are considered to be an effective remedy in Ghana for the management of skin diseases and wounds. Bioactivity-guided fractionation of the chloroform extract of the root bark of the plant has resulted in the isolation of a novel cassane-type furanoditerpenoid, designated as benthaminin 3. The structure of the compound was elucidated by the use of spectroscopic techniques. The antibacterial activity of the compound has been assessed using the microdilution assay method. The lowest MIC (63μg/mL) was recorded against Staphylococcus aureus and Bacillus subtilis. The compound wasalso observed to have a mild inhibitory effect against resistant strains of bacteria including methicillin-resistant S. aureus, tetracyline-resistant S. aureus and erythromycin-resistant S. aureus with MIC values greater than 1000μg/mL.

https://doi.org/10.6000/1927-5951.2012.02.01.3
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References

Herendeen PS, and Zarucchi JL. Validation of Caesalpinia subgenus Mezoneuron (Desf.) vidal and new combinations in Caesalpinia for two species from Africa. Ann Missouri Botanical Garden 1990; 77: 854-55. http://dx.doi.org/10.2307/2399679

Irvine FR. Woody Plants of Ghana. Oxford University Press, London 1961; pp. 312-313.

Abbiw D. Useful Plants of Ghana. Intermediate Technical Publications and Royal Botanic Gardens, Kew, 1990; 199-200.

Attah Y. Personal communication 2003.

Banskota F, Attamimi TZ, Usia YT, Linn SK, Kadota S. Novel norcassane-type diterpene from the seed kernels of Caesalpinia crista. Tetrahedron Lett 2003; 6879-82. http://dx.doi.org/10.1016/S0040-4039(03)01722-2

Jiang RW, Paul PHB, Shuang-Cheng MA, Thomas CWM. New antiviral cassane furanoditerpenes from Caesalpinia minax. J Nat Prod 2001; 1266-1272. http://dx.doi.org/10.1021/np010174+

Mbagwu HOC, Anene RA, Adeyemi OO. Anti-diarrhoeal activity of the aqueous extract of Mezoneuron benthamianum Baill (Caesalpiniaceae). J Ethnopharmacol 2008; 16-20. http://dx.doi.org/10.1016/j.jep.2007.10.037

Dickson RA, Houghton PJ, Hylands, PJ. Antibacterial and antioxidant cassane diterpenoids from Caesalpinia benthamiana. Phytochemistry 2007; 1436-41. http://dx.doi.org/10.1016/j.phytochem.2007.03.008

Kitagawa I, Simanjuntak P, Mahmud T, et al. Indonesian medicinal plants.XIII: chemical structures of caesaldekarins c, d, and e, three additional cassane-type furanoditerpenes from the roots of Caesalpinia major (Fabaceae). Several interesting reaction products of caesaldekarin a provided by N-bromosuccinimide treatment. Chem Pharmaceut Bull 1996; 1157-61. http://dx.doi.org/10.1248/cpb.44.1157

King FE, Godson DH, King TJ. The chemistry of extractives from heartwoods. J Chem Soc 1955; 1117-19.

Peter S, Tinto WF, McLean S, Reynolds WF, Yu M. Cassane diterpenes from Caesalpinia bonducella. Phytochemistry 1998; 1153-55.

Houghton PJ, Hylands PJ, Mensah AY, Hensel A, Deters AM. In- vitro tests and ethnopharmacological investigations: Wound healing as an example. J Ethnopharmacol 2005; 100: 100-107. http://dx.doi.org/10.1016/j.jep.2005.07.001

Thomas S. Wound Management and Dressings. The Pharmaceutical Press London 1990; 6-7.

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Copyright (c) 2012 Rita A. Dickson, Kofi Annan, Theophilus C. Fleischer , Peter J. Houghton