Keywords
Sympathetic Nervous System
Exercise
Blood Pressure
Heart Rate
Post-Exercise Hypotension
How to Cite
Abstract
Objective: to evaluate the blood pressure (BP) behavior and sympathetic activity in response to an aerobic exercise session after taking a dose of Nutrex Lipo-6 Black®.
Methods: This randomized, placebo-controlled study utilized seventeen subjects, divided in supplementation (n=10, 26.5±5.3 years) and placebo groups (n=7, 22.4±2.8 years). They ingested a dose of Nutrex Lipo-6 Black® (containing synephrine, caffeine, yohimbine and diiodine) or placebo and underwent a session of 40min of aerobic exercise of moderate intensity. Heart rate (HR), BP and cardiac autonomic balance (measured by heart rate variability) (CANA) were monitored at baseline, 30min after supplementation, at the end of the exercise and every 10min during a recovery period of 30min.
Results: After 30min of intake, Nutrex Lipo-6 Black® and placebo groups exhibited HR, BP and CANA similar to each other and in relation to the pre-supplementation moment. At the end of the exercise all variables showed a rise in relation to rest, but without statistical difference between groups (p>0,05). Moreover, at 30min of recovery, the Nutrex Lipo-6 Black® group presented with diastolic hypertensive response (increase of 4.2 mmHg) and a discrete post-exercise hypotension only to systolic pressure (-0.2 mmHg) relative to the pre-supplementation, while the placebo group showed evident both systolic and diastolic hypotension (-6.3 and -0.5 mmHg, respectively). HR and CANA were similar to pre-supplementation at this time.
Conclusion: single dose of Nutrex Lipo-6 Black® is able to limit the benefits of an exercise session in reducing BP, even without affecting the resting conditions of BP and CANA.
References
Lun V, Erdman KA, Fung TS, Reimer RA. Dietary supplementation practices in Canadian high-performance athletes. Int J Sport Nutr Exerc Metab 2012; 22(1): 31-7.
Braun H, Koehler K, Geyer H, Kleiner J, Mester J, Schanzer W. Dietary supplement use among elite young German athletes. Int J Sport Nutr Exerc Metab 2009; 19(1): 97-109.
Bianco A, Mammina C, Paoli A, Bellafiore M, Battaglia G, Caramazza G, et al. Protein supplementation in strength and conditioning adepts: knowledge, dietary behavior and practice in Palermo, Italy. J Int Soc Sports Nutr 2011; 8(1): 25. http://dx.doi.org/10.1186/1550-2783-8-25
Molinero O, Márquez S. Use of nutritional supplements in sports: risks, knowledge, and behavioural-related factors. Nutr Hosp 2009; 24(2): 128-34.
Weiss EC, Galuska DA, Khan LK, Serdula MK. Weight-control practices among U.S. adults, 2001-2002. Am J Prev Med 2006; 31(1): 18-24. http://dx.doi.org/10.1016/j.amepre.2006.03.016
Silva AS, Paulo S, Zanesco A. Exercício físico, receptores ß-adrenérgicos e resposta vascular. J Vasc Bras 2010; 9(2): 47-56.
Kreider RB, Wilborn CD, Taylor L, Campbell B, Almada AL, Collins R, et al. ISSN exercise & sport nutrition review: research & recommendations. J Int Soc Sports Nutr 2010; 7(7): 2-43.
Bent S, Tiedt T, Odden M, Shlipak M. The relative safety of ephedra compared with other herbal products. Ann Internal Med 2003; 138(6): 468-71.
Maglione M, Miotto K, Iguchi M, Hilton L, Shekelle P. Psychiatric symptoms associated with ephedra use. Expert Opin Drug Saf 2005; 4(5): 879-40. http://dx.doi.org/10.1517/14740338.4.5.879
Shekelle P, Hardy M, Morton S, Maglione M, Mojica W, Suttorp M, et al. Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: a meta-analysis. JAMA 2003; 289(12): 1537-45. http://dx.doi.org/10.1001/jama.289.12.1537
Thomas J, Munir J, McIntyre P, Ferguson M. STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Tex Heart Inst J 2009; 36(6): 586-90.
Bui L, Nguyen D, Ambrose P. Blood pressure and heart rate effects following a single dose of bitter orange. Ann Pharmacother 2006; 40(1): 53-70. http://dx.doi.org/10.1345/aph.1G488
Cazé R, Franco G, Porpino S, Souza A, Padilhas O, Silva A. Caffeine influence on blood pressure response to aerobic exercise in hypertensive subjects. Rev Bras Hipertens 2010; 16(6): 324-8.
Junior JSM, Nóbrega TKS, Brito AF, Silva AS. Influência Aguda do Tabaco na Pressão Arterial, Freqüência Cardíaca e na Hipotensão Pós-Exercício em homens Jovens Fumantes. Rev Bras Ciênc Saúde 2011; 14(4): 57-64.
Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA. Exercise and Hypertension. Med Sci Sports Exerc 2004; 36(3): 533-53. http://dx.doi.org/10.1249/01.MSS.0000115224.88514.3A
Brandão A. VI Diretrizes Brasileiras de Hipertensão. Arquivos Brasileiros de Cardiologia 2010; 13(1).
Karvonen M, Kentala E, Mustala O. The effects of training on heart rate: a longitudinal study. Ann Med Exper Fenn 1957; 35(3): 307-15.
Notarius C, Morris B, Floras J. Caffeine attenuates early post-exercise hypotension in middle-aged subjects. Am J Hypertens 2006; 19(2): 184-8. http://dx.doi.org/10.1016/j.amjhyper.2005.07.022
Laterza M, Rondon M, Negrão C. Efeito anti-hipertensivo do exercício. Rev Bras Hiperten 2007; 14(2): 104-11.
Haller C, Duan M, Jacob P, Benowitz N. Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions. Br J Clin Pharmacol 2008; 65(6): 833-40. http://dx.doi.org/10.1111/j.1365-2125.2008.03144.x
Mcbride BF, Karapanos AK, Krudysz A, Kluger J, Coleman CI, White CM. Electrocardiographic and Hemodynamic Supplement Containing Ephedra. JAMA 2004; 291(2).
Haller C, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000; 343(25): 1833-8. http://dx.doi.org/10.1056/NEJM200012213432502
Hackman RM, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, et al. Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial. Int J Obes (Lond) 2005; 30(10): 1545-56. http://dx.doi.org/10.1038/sj.ijo.0803283
Stephensen T, Sarlay Rj. Ventricular fibrillation associated with use of synephrine containing dietary supplement. Military Med 2009; (174): 1313-9.
Seifert JG, Nelson A, Devonish J, Burke ER, Stohs SJ. Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans. Int J Med Sci 2011; 8(3): 192-7. http://dx.doi.org/10.7150/ijms.8.192
Arch J. ?-3-Adrenoreceptor agonists: potential, pitfalls and progress. Eur J Pharmacol 2002; 12(440): 99-107. http://dx.doi.org/10.1016/S0014-2999(02)01421-8
Tsujita T, Takaku T. Lipolysis induced by segment wall extract from Satsuma mandarin orange (Citrus unshu Mark). J Nutr Sci Vitaminol (Tokyo) 2007; 53(6): 547-51. http://dx.doi.org/10.3177/jnsv.53.547
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright (c) 2013 Leonardo Medeiros Magalhães, Caio Victor Coutinho de Oliveira, Maria da Conceição Rodrigues Gonçalves, Alesandra Araújo de Souza , Alexandre Sérgio Silva